135365-62-7

Basic information

• Product Name: 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate]
• Synonyms: 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate]
• CAS NO: 135365-62-7
• Molecular Weight: 1082.45
• Mol File: 135365-62-7.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate](CAS DataBase Reference)
• NIST Chemistry Reference: 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate](135365-62-7)
• EPA Substance Registry System: 1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate](135365-62-7)

Safety Data

• Hazardous Substances Data: 135365-62-7(Hazardous Substances Data)

Upstream product

• 994-30-9 triethylsilyl chloride 
• 33069-62-4 paclitaxel 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 149249-91-2 (3R,4S)-1-benzoyl-4-phenyl-3-(triethylsilyl)oxy-2-azetidinone 
• 33069-62-4 taxol 
• 32981-86-5 10-deacetylbaccatin III 
• 27548-93-2 baccatin III 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 155588-19-5 C₂₈H₄₄O₉Si 
• 155588-11-7 C₂₉H₄₂O₁₀Si 
• 155588-12-8 C₃₁H₄₄O₁₁Si 
• 155588-21-9 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III 
• 150665-56-8 7-O-triethylsilyl-13-keto baccatin III 
• 150541-99-4 7,13-O,O-Bis(triethylsilyl)baccatin III 

Downstream Products

• 144757-75-5 (1α)-15(16)-anhydro-7-(triethylsilyl-11(15->1)-abeotaxol 
• 135365-63-8 (1α)-15(16)-anhydro-2',7-bis(triethylsilyl)-11(15->1)-abeotaxol 
• 33069-62-4 taxol 
• 156266-04-5 2-O-debenzoyl-2',7-bis(O-triethylsilyl)paclitaxel 
• 115437-21-3 7-(triethylsilyl)baccatin III 
• 148930-55-6 7-O-(triethylsilyl)paclitaxel 
• 164735-02-8 1-Benzoyl-2-<(S-methyldithio)carbonyl>-2',7-bis(triethylsilyl)paclitaxel 
• 156266-09-0 C₆₀H₇₈N₂O₁₄Si₂ 
• 156266-05-6 C₅₉H₇₈N₄O₁₄Si₂ 
• 135365-64-9 A-nor-paclitaxel 
• 717094-03-6 15,16-epoxy-A-nor-paclitaxel 
• 205750-03-4 1-deisopropenyl-1-acetyl-A-norpaclitaxel 

Relevant articles and documents

Total Synthesis of Paclitaxel

The total synthesis of paclitaxel (Taxol) is described. Double Rubottom oxidation of the bis(silyl enol ether) derived from a tricarbocyclic diketone effectively installed a bridgehead olefin and C-5/C-13 hydroxy groups in a one-step operation. The novel Ag-promoted oxetane formation smoothly constructed the tetracyclic framework of paclitaxel.

PROCESS FOR PREPARING TAXOIDS FROM BACCATIN DERIVATIVES USING LEWIS ACID CATALYST

The present invention relates to a process of preparing a taxoid (X) by reacting a protected baccatin derivative (B) with a β-lactam (C) in the presence of one or more Lewis acids and a base agent. The present invention also relates to a process of preparing the protected baccatin derivative (B) from a baccatin derivative (A) comprising a protection reaction catalyzed by one or more Lewis acids with an optional base agent.

Beta-Lactams useful for preparation of substituted isoserine esters using metal alkoxides

β-lactams are disclosed which are useful for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted esters by reaction with a metal alkoxide.