1361023-39-3

Basic information

• Product Name: N-(4-hydroxybenzylidene)-3-cyclohexylpropionic acid hydrazide
• CAS NO: 1361023-39-3
• Molecular Weight: 274.363
• Mol File: 1361023-39-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-hydroxybenzylidene)-3-cyclohexylpropionic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxybenzylidene)-3-cyclohexylpropionic acid hydrazide(1361023-39-3)
• EPA Substance Registry System: N-(4-hydroxybenzylidene)-3-cyclohexylpropionic acid hydrazide(1361023-39-3)

Safety Data

• Hazardous Substances Data: 1361023-39-3(Hazardous Substances Data)

Upstream product

• 10094-36-7 ethyl 3-cyclohexylpropanoate 
• 81975-20-4 β-Cyclohexylpropionic acid hydrazide 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of some hydrazone derivatives as anti-inflammatory agents

In the present study, some hydrazone derivatives were synthesized via the reaction of 3-cyclohexylpropionic acid hydrazide with various benzaldehydes. The chemical structures of the compounds were elucidated by spectroscopic techniques such as IR, 1H-NMR and FAB-MS and elemental analyses. The compounds were evaluated for their antiinflammatory and cytotoxic activities. Anti-inflammatory activity was determined in terms of inhibition of NF-κB, ROS generation and iNOS activity. Several derivatives inhibited NF-κB and iNOS, but no effect was observed on intracellular ROS generation. Furthermore no cytoxicity was observed. Biological activity compared with the chemical structural information suggests that different functional groups on the phenyl ring influence the physicochemical properties and thus modulate biological activity.