1364510-20-2

Basic information

• Product Name: 3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• Synonyms: 3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
• CAS NO: 1364510-20-2
• Molecular Weight: 276.264
• Mol File: 1364510-20-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one(1364510-20-2)
• EPA Substance Registry System: 3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one(1364510-20-2)

Safety Data

• Hazardous Substances Data: 1364510-20-2(Hazardous Substances Data)

Upstream product

• 128837-25-2 1-[2,4-bis(ethoxymethoxy)-6-hydroxyphenyl]ethan-1-one 
• 459-57-4 4-fluorobenzaldehyde 
• 108-73-6 3,5-dihydroxyphenol 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 1311281-47-6 C₁₉H₁₉FO₆ 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Relevant articles and documents

Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives

A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8, 9, 12, 45, 46 and 48) displayed powerful antiproliferative effects to certain human tumor cells, but all of them were devoid of any cytotoxicity towards the normal HEK 293. Acridine orange staining data supported that the cytotoxic and antiproliferative effects of the synthesized analogs on tumor cells are mediated through apoptosis. The compounds 12 and 46 manifested concentration-dependent antiproliferative activity in human hepatocellular carcinoma cell lines using an xCELLigence assay. The structures and antiproliferative activity relationship were further supported by in silico molecular docking study of the compounds against tubulin protein which suggests our compounds interference to cell division. Communicated by Ramaswamy H. Sarma.

Base-catalyzed oxidative dearomatization of multisubstituted phloroglucinols: An easy access to C-glucosyl 3,5,6-trihydroxycyclohexa-2,4-dienone derivatives

An efficient and simple method for the protecting group-free synthesis of C-glucosyl 3,5,6-trihydroxycyclohexa-2,4-dienone has been firstly established. This method is compatible with various functional groups, such as benzyl and phenethyl groups, affording a range of C-glucosyl 3,5,6-trihydroxycyclohexa-2,4-dienone derivatives.

ANTIBACTERIAL AGENTS: PHLOROGLUCINOL DERIVATIVES

The invention provides a compound of formula I: or a salt thereof, wherein R1-R3 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.