1367359-28-1

Basic information

• Product Name: (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one
• Synonyms: (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one
• CAS NO: 1367359-28-1
• Molecular Weight: 489.387
• Mol File: 1367359-28-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one(1367359-28-1)
• EPA Substance Registry System: (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one(1367359-28-1)

Safety Data

• Hazardous Substances Data: 1367359-28-1(Hazardous Substances Data)

Upstream product

• 75-30-9 2-iodo-propane 
• 866807-27-4 3-amino-6-chloro-pyridine-2-carboxylic acid 
• 175358-01-7 3-amino-6-chloro-pyridine-2-carboxylic acid amide 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 2105-94-4 4-bromo-2-fluorophenol 
• 1367359-18-9 6-chloro-3-[[(3S)-1-isopropyl-3-piperidyl]methyl]-2-methylpyrido[3,2-d]pyrimidin-4-one 
• 1367359-47-4 3-amino-6-chloropyridine-2-carboxylic acid ((R)-1-isopropylpiperidin-3-ylmethyl)amide 
• 866775-04-4 3-amino-6-chloropyridine-2-carboxylic acid dihydrochloride 

Relevant articles and documents

Development of fluorinated Non-Peptidic ghrelin receptor ligands for potential use in molecular imaging

The ghrelin receptor (GhrR) is a widely investigated target in several diseases. However, the current knowledge of its role and distribution in the brain is limited. Recently, the small and non-peptidic compound (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one ((S)-9) has been described as a GhrR ligand with high binding affinity. Here, we describe the synthesis of fluorinated derivatives, the in vitro evaluation of their potency as partial agonists and selectivity at GhrRs, and their physicochemical properties. These results identified compounds (S)-9, (R)-9, and (S)-16 as suitable parent molecules for18F-labeled positron emission tomography (PET) radiotracers to enable future investigation of GhrR in the brain.