1367740-01-9

Basic information

• Product Name: (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid
• CAS NO: 1367740-01-9
• Molecular Weight: 319.281
• Mol File: 1367740-01-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid(1367740-01-9)
• EPA Substance Registry System: (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid(1367740-01-9)

Safety Data

• Hazardous Substances Data: 1367740-01-9(Hazardous Substances Data)

Usage

Description

(R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid is a chemical compound that belongs to the propanoic acid derivatives. It features a tert-butoxycarbonylamino functional group at the 2-position and a 2,4,5-trifluorophenyl group at the 3-position. (R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid holds potential for various applications in the pharmaceutical industry, particularly as a building block in the synthesis of biologically active molecules or as a potential drug candidate itself. Its specific properties and pharmacological activities are yet to be fully explored through further research and testing.

Uses

Used in Pharmaceutical Industry:
(R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid is used as a building block for the synthesis of biologically active molecules due to its unique structural features, including the tert-butoxycarbonylamino and trifluorophenyl groups.
Used in Drug Development:
(R)-2-(tert-butoxycarbonylamino)-3-(2,4,5-trifluorophenyl)propanoic acid is used as a potential drug candidate in the pharmaceutical industry, with its properties being investigated for possible therapeutic uses and pharmacological activities. Further research may reveal its effectiveness in treating specific medical conditions or diseases.

Upstream product

• 144284-25-3 (2,4,5-trifluorophenyl)methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 486460-07-5 (2S,5R)-2,5-dihydro-3,6-dimethoxy-2-isopropyl-5-(2',4',5'-trifluorobenzyl)-pyrazine 
• 157911-56-3 2,4,5-trifluorobenzyl bromide 
• 486460-08-6 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate 

Downstream Products

• 654671-78-0 sitagliptin phosphate 

Relevant articles and documents

Efficient stereocontrolled synthesis of sitagliptin phosphate

The synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from the chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving highly stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.

FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

PIPERIDINO PYRIMIDINE DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.