137449-25-3

Basic information

• Product Name: 1-ethyl-3-methyl-2-phenyl-1H-indole
• Synonyms: 1-ethyl-3-methyl-2-phenyl-1H-indole
• CAS NO: 137449-25-3
• Molecular Weight: 235.329
• Mol File: 137449-25-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-ethyl-3-methyl-2-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-3-methyl-2-phenyl-1H-indole(137449-25-3)
• EPA Substance Registry System: 1-ethyl-3-methyl-2-phenyl-1H-indole(137449-25-3)

Safety Data

• Hazardous Substances Data: 137449-25-3(Hazardous Substances Data)

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 612-64-6 N-ethyl-N-nitrosoaniline 
• 103-69-5 N-ethyl-N-phenylamine 
• 14321-27-8 N-ethylbenzylamine 
• 446-52-6 2-Fluorobenzaldehyde 
• 1037132-05-0 2-(benzyl(ethyl)amino)benzaldehyde 
• 67-68-5 dimethyl sulfoxide 
• 826-42-6 N,N-diethylaniline N-oxide 
• 644-21-3 1-ethyl-1-phenylhydrazine 
• 78388-92-8 1-(3-methyl-2-phenyl-1H-indol-1-yl)ethan-1-one 

Relevant articles and documents

Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans

An efficient and facile method to synthesize valuable disubstituted 2-aryl indoles and benzofurans in good yields has been demonstrated, based on a tert-butoxide-mediated condensation reaction involving a vinyl sulfoxide intermediate. Products are obtained from N- or O-benzyl benzaldehydes using dimethyl sulfoxide as a carbon source. The methodology features a wide functional group tolerance and transition metal-free environment. Preliminary mechanistic studies suggest that the reaction involves a tandem aldol reaction/Michael addition/dehydrosulfenylation/isomerization sequence through an ionic protocol.

A method for synthesis of indole compounds

The invention provides a method for synthesizing an indole compound. The method comprises the following steps of adding alkali into 2-acyl-N,N-disubstituted phenylamine which serves as a raw material under the protection of nitrogen, and heating the mixture in a solvent to obtain the high-yield indole compound. The raw material is readily available, and the method is convenient to operate, short in reaction time and high in reaction yield, and has high practical value for the industrial preparation of the indole compound.

Ruthenium(II)-Catalyzed Traceless C?H Functionalization Using an N?N Bond as an Internal Oxidant

A previously elusive RuII-catalyzed N?N bond-based traceless C?H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C?H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.