13754-56-8 Usage
Description
DIOXOPROMETHAZINE HCL, also known as Promethazine Sulfone, is a metabolite of Promethazine, a drug belonging to the antihistamine family. It exhibits strong sedative effects and possesses antiemetic and anticholinergic properties, making it a versatile compound with various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
DIOXOPROMETHAZINE HCL is used as a sedative for its strong sedative effects, which help in the treatment of insomnia in some countries. Its calming properties make it a valuable component in the management of sleep disorders and anxiety-related conditions.
DIOXOPROMETHAZINE HCL is also used as an antiemetic to alleviate nausea and vomiting, making it a useful compound in the treatment of various conditions that cause these symptoms, such as motion sickness, chemotherapy-induced nausea, and postoperative recovery.
Furthermore, DIOXOPROMETHAZINE HCL is utilized as an anticholinergic agent, which helps in reducing the effects of acetylcholine, a neurotransmitter. This property is beneficial in the treatment of various conditions, including Parkinson's disease, where it can help alleviate symptoms like tremors and muscle stiffness.
Check Digit Verification of cas no
The CAS Registry Mumber 13754-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,5 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13754-56:
(7*1)+(6*3)+(5*7)+(4*5)+(3*4)+(2*5)+(1*6)=108
108 % 10 = 8
So 13754-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N2O2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)22(20,21)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
13754-56-8Relevant articles and documents
Green technology for preparing dioxopromethazine hydrochloride by using oxygen as oxidant
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Paragraph 0013, (2017/07/21)
The invention discloses a green technology for preparing dioxopromethazine hydrochloride by using oxygen as an oxidant, and belongs to the technical field of medical intermediates. The green technology is characterized in that a target product-the dioxopromethazine hydrochloride can be obtained through a series of reaction by using the oxygen as the oxidant and adopting palladium acetate as a catalyst, and a production process is greatly simplified; compared with a method of using hydrogen peroxide as the oxidant, the yield of an intermediate is much higher, a whole oxidation process requires no addition of sulfuric acid or the hydrogen peroxide, a final product is powder which is white to yellowish or crystalline powder, and the final product is odorless and is bitter in taste and very high in purity. By adopting an improved synthesis path, the green technology disclosed by the invention has multiple advantages that the yield is increased to a large extent, the cost is reduced, safety is increased, energy is saved, and the like, and modern chemical industry production requirements of green reaction are met.
