137736-63-1

Basic information

• Product Name: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine
• Synonyms: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine
• CAS NO: 137736-63-1
• Molecular Formula: C₁₂H₇BrF₃NO
• Molecular Weight: 318.0892896
• Product Categories: Halides;Phenyls & Phenyl-Het
• Mol File: 137736-63-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 328.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.567±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.18±0.22(Predicted)
• CAS DataBase Reference: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(137736-63-1)
• EPA Substance Registry System: 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine(137736-63-1)

Safety Data

• Hazardous Substances Data: 137736-63-1(Hazardous Substances Data)

Usage

General Description

2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C12H7BrF3NO. It is a pyridine derivative, and its structure consists of a pyridine ring with a bromophenoxy group at position 2 and a trifluoromethyl group at position 5. 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is used in various scientific and industrial applications, including as a building block for the synthesis of pharmaceuticals and agrochemicals. It can also be used as an intermediate in the production of organic compounds and as a reagent in chemical reactions. Due to its specific chemical properties, 2-(4-bromophenoxy)-5-(trifluoromethyl)pyridine is valued for its role in the development of new materials and substances in the fields of medicine, agriculture, and chemistry.

Upstream product

• 106-41-2 4-bromo-phenol 
• 100366-75-4 2‐iodo‐5‐(trifluoromethyl)pyridine 
• 52334-81-3 2-chloro-5-trifluoromethylpyridine 

Downstream Products

• 1433051-75-2 (E)-ethyl 3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)acrylate 
• 1433051-80-9 (2R,3S)-ethyl 2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)-phenyl)-1H-indol-3-yl)propanoate 
• 1433050-31-7 (2R,3S)-2,3-dihydroxy-3-(1-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-1H-indol-3-yl)propanamide 
• 1355052-60-6 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-5-(trifluoromethyl)pyridine 
• 1354745-74-6 6-chloro-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinolin-4(1H)-one 
• 1599467-89-6 6-chloro-4-ethoxy-7-methoxy-2-methyl-3-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)quinoline 

Relevant articles and documents

Discovery, synthesis, and optimization of antimalarial 4(1 H)-quinolone-3-diarylethers

The historical antimalarial compound endochin served as a structural lead for optimization. Endochin-like quinolones (ELQ) were prepared by a novel chemical route and assessed for in vitro activity against multidrug resistant strains of Plasmodium falciparum and against malaria infections in mice. Here we describe the pathway to discovery of a potent class of orally active antimalarial 4(1H)-quinolone-3-diarylethers. The initial prototype, ELQ-233, exhibited low nanomolar IC50 values against all tested strains including clinical isolates harboring resistance to atovaquone. ELQ-271 represented the next critical step in the iterative optimization process, as it was stable to metabolism and highly effective in vivo. Continued analoging revealed that the substitution pattern on the benzenoid ring of the quinolone core significantly influenced reactivity with the host enzyme. This finding led to the rational design of highly selective ELQs with outstanding oral efficacy against murine malaria that is superior to established antimalarials chloroquine and atovaquone.

HETEROARYL COMPOUNDS AS SODIUM CHANNEL BLOCKERS

The invention relates to aryl substituted compounds of Formula (I) : and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein Het, G, A, R, and n are defined as set forth in the specification. The invention is also directed to the use