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1380243-35-5

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1380243-35-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1380243-35-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,0,2,4 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1380243-35:
(9*1)+(8*3)+(7*8)+(6*0)+(5*2)+(4*4)+(3*3)+(2*3)+(1*5)=135
135 % 10 = 5
So 1380243-35-5 is a valid CAS Registry Number.

1380243-35-5Relevant articles and documents

Efficient synthesis of sitagliptin phosphate, a novel DPP-IV inhibitor, via a chiral aziridine intermediate

Pan, Xianhua,Li, Xiaojun,Lu, Qingling,Yu, Wansheng,Li, Weijin,Zhang, Qunhui,Deng, Fei,Liu, Feng

, p. 6807 - 6809 (2013)

Sitagliptin phosphate, a novel DPP-IV inhibitor of T2DM, has been synthesized via 12 linear steps, in an overall yield of 26%. The key step is the coupling reaction of 2,4,5-trifluorophenylmagnesium bromide with a chiral aziridine derivative, which was prepared from l-homo-serine by simple steps.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

-

, (2013/11/05)

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.

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