13860-45-2

Basic information

• Product Name: 1,4-dimethoxyphenazine
• CAS NO: 13860-45-2
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.2573
• Mol File: 13860-45-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 435°C at 760 mmHg
• Flash Point: 156.7°C
• Density: 1.25g/cm³
• Vapor Pressure: 2.3E-07mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 1,4-dimethoxyphenazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dimethoxyphenazine(13860-45-2)
• EPA Substance Registry System: 1,4-dimethoxyphenazine(13860-45-2)

Safety Data

• Hazardous Substances Data: 13860-45-2(Hazardous Substances Data)

Usage

Chemical class

Phenazine

Structure

Central phenazine ring with two methoxy groups attached at the 1 and 4 positions

Applications

Organic electronic devices (OLEDs and OPVs)

Properties

High electron-affinity and good charge transport

Potential uses

Pharmaceutical and biomedical fields

Investigated properties

Antioxidant and anti-inflammatory

Versatility

Applications in various industries, including electronics and healthcare

Upstream product

• 855375-39-2 6,9-dimethoxy-1,2,3,4-tetrahydro-phenazine 
• 89-39-4 1,4-dimethoxy-2-nitrobenzene 
• 62-53-3 aniline 
• 98-95-3 nitrobenzene 
• 102-56-7 2,5-dimethoxyaniline 
• 583-63-1 ortoquinone 
• 40328-95-8 2,3-diamino-1,4-dimethoxybenzene 
• 6945-76-2 1,4-dimethoxy-2,3-dinitrobenzene 
• 108-88-3 toluene 

Relevant articles and documents

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Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from streptomyces species, strain CNS284

The isolation of 2-bromo-1-hydroxyphenazine from a marine Streptomyces species, strain CNS284, and its activity against NF-κB, suggested that a short and flexible route for the synthesis of this metabolite and a variety of phenazine analogues should be developed. Numerous phenazines were subsequently prepared and evaluated as inducers of quinone reductase 1 (QR1) and inhibitors of quinone reductase 2 (QR2), NF-κB, and inducible nitric oxide synthase (iNOS). Several of the active phenazine derivatives displayed IC50 values vs QR1 induction and QR2 inhibition in the nanomolar range, suggesting that they may find utility as cancer chemopreventive agents.