139063-68-6

Basic information

• Product Name: ethyl 2,2-difluoro-4-phenylbutanoate
• Synonyms: ethyl 2,2-difluoro-4-phenylbutanoate
• CAS NO: 139063-68-6
• Molecular Weight: 228.239
• Mol File: 139063-68-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ethyl 2,2-difluoro-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2,2-difluoro-4-phenylbutanoate(139063-68-6)
• EPA Substance Registry System: ethyl 2,2-difluoro-4-phenylbutanoate(139063-68-6)

Safety Data

• Hazardous Substances Data: 139063-68-6(Hazardous Substances Data)

Upstream product

• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 100-42-5 styrene 
• 698378-63-1 ethyl α,α-difluoro-α-(phenylseleno)acetate 

Downstream Products

• 915132-88-6 (R,S)-2-{[6-(2,2-difluoro-4-phenylbutoxy)hexyl]amino}-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol 
• 915132-87-5 {4-[(6-bromohexyl)oxy]-3,3-difluorobutyl}benzene 
• 177996-67-7 β-difluoro-γ-methylbenzene propanol 
• 1352954-30-3 C₂₁H₂₃F₂NO₃ 
• 1352954-06-3 4-(3,3-difluoro-5-phenylpent-1-en-2-yl)benzoic acid 
• 1352954-29-0 C₁₉H₁₈F₂O₂ 
• 1352954-28-9 C₁₈H₁₆F₂O₃ 
• 1352954-27-8 C₁₇H₁₄F₂O₃ 
• 1352954-26-7 C₁₂H₁₅F₂NO₂ 

Relevant articles and documents

Electrosynthesis of ethyl α, α-difluoro-α-(phenylseleno)acetate and its photochemical synthetic application

Anodic fluorination of ethyl α-fluoro-α-(phenylseleno) acetate was successfully carried out to give ethyl α,α -difluoro-α-(phenylseleno)acetate in high yield. Photolysis of the difluorinated product in the presence of various olefins provided regioselective difluorometylene adducts in good to moderate total yields. The reaction involves phenylselenyl transfer at the early stage followed by the elimination of a phenylselenyl group from the adducts once formed to provide the unsaturated and saturated difluoromethylene products.

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

The present invention provides a compound of formula (I) wherein: R1 is a group selected from -CH2OH, -NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R2; R3 is selected from hydrogen and halogen atoms or groups selected from -SO-R5, -SO2- R5, -NH-CO-NH2, -CO-NH2, hydantoino, C1-4alkyl, C1-4alkoxy and -SO2NR5R6; R4 is selected from hydrogen atoms, halogen atoms and C1-4alkyl groups; R5 is a C1-4alkyl group or C3-8 cycloalkyl; R6 is independently selected from hydrogen atoms and C1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.

PHOSPHOLIPASE A2 INHIBITORS

There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma, psoriasis, inflammatory bowel disease and inflammation in mammals which comprises administering to a mammal so afflicted an effective am