1391870-16-8Relevant articles and documents
Selective N-alkylation of arylamines with alkyl chloride in ionic liquids: Scope and applications
Monopoli, Antonio,Cotugno, Pietro,Cortese, Marina,Calvano, Cosima Damiana,Ciminale, Francesco,Nacci, Angelo
, p. 3105 - 3111 (2012)
An efficient N-selective alkylation of primary aromatic amines in molten quaternary ammonium salts, as the solvent, under relatively mild and base-free conditions is presented. On the basis of the Kamlet-Taft parameters and the nucleophilicity of the IL (ionic liquid) anions, the influence of the ionic liquid was evaluated. This protocol was validated on a larger multigram scale and with the syntheses of bioactive heterocycles (e.g., 1,4-benzothiazine and quinoxalines) and new efficient MALDI matrixes. Copyright