1392-21-8

Basic information

• Product Name: Sineptina
• Synonyms: LEUCOMYCIN HYDRATE;KITASAMYCIN BASE;KITASAMYCIN;FORMACIDINE;ayermicina;c637;selectomycin;Leucomycin Base
• CAS NO: 1392-21-8
• Molecular Formula: C35H59NO13
• Molecular Weight: 701.84186
• EINECS: 232-429-6
• Mol File: 1392-21-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 128-145 °C
• Boiling Point: 849.4 °C at 760 mmHg
• Flash Point: 467.5 °C
• Appearance: Light yellow or brown flowable powder
• Density: 1.17 g/cm³
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• Solubility: ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
• Water Solubility: ethanol: 50 mg/mL, clear to slightly hazy, light-yellow
• Merck: 14,5453
• CAS DataBase Reference: Sineptina(CAS DataBase Reference)
• NIST Chemistry Reference: Sineptina(1392-21-8)
• EPA Substance Registry System: Sineptina(1392-21-8)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 1
• RTECS: WG9400000
• F: 10
• Hazardous Substances Data: 1392-21-8(Hazardous Substances Data)

Usage

Description

Sineptina is a family of closely related macrocyclic lactone antibiotics that were produced by Streptomyces kitasatoensis and discovered in 1953. The complex contains over 14 components, with analogues A1, A4, A5, and A13 being the most abundant. These antibiotics exhibit potent antimicrobial properties, making them valuable in various applications.

Uses

Used in Animal Health:
Sineptina is utilized as an animal health product for the control of various bacterial infections, including those caused by Gram-positive bacteria, Gram-negative cocci, leptospira, and mycoplasma. Its effectiveness in treating these infections contributes to the overall well-being and health of animals.
Used in Organic Synthesis:
Leucomycins, which are part of the Sineptina family and constitute more than 85% of the compound (CAS# 1392-21-8), are useful in organic synthesis. Their unique chemical properties allow them to be employed in the creation of various compounds and materials, further expanding the utility of Sineptina in different industries.

Pharmaceutical Applications

A naturally occurring product of Streptomyces kitasatoensis, available in Japan for parenteral and oral use, and as acetylkitasamycin for topical application. Elsewhere it is chiefly used in veterinary medicine.

InChI:InChI=1/C41H69NO13/c1-23(2)19-31(46)53-39-27(6)51-33(22-41(39,7)8)54-36-26(5)52-40(35(48)34(36)42(9)10)55-37-28(17-18-43)20-24(3)29(44)16-14-12-13-15-25(4)50-32(47)21-30(45)38(37)49-11/h12-14,16,18,23-30,33-40,44-45,48H,15,17,19-22H2,1-11H3/b13-12+,16-14+/t24-,25-,26?,27?,28?,29?,30-,33?,34?,35?,36?,37+,38+,39?,40?/m1/s1