13935-80-3

Basic information

• Product Name: N-INDAN-2-YL-ACETAMIDE
• Synonyms: N-INDAN-2-YL-ACETAMIDE;N-2-Indanyl-acetaMide;N-(2,3-dihydro-1H-inden-2-yl)acetaMide;AcetaMide,N-(2,3-dihydro-1H-inden-2-yl)-
• CAS NO: 13935-80-3
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 13935-80-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 373.543°C at 760 mmHg
• Flash Point: 220.91°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: N-INDAN-2-YL-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-INDAN-2-YL-ACETAMIDE(13935-80-3)
• EPA Substance Registry System: N-INDAN-2-YL-ACETAMIDE(13935-80-3)

Safety Data

• Hazardous Substances Data: 13935-80-3(Hazardous Substances Data)

Usage

General Description

N-Indan-2-yl-acetamide is a chemical compound which comes under the category of organic compounds. The systematic name of this compound is N-(2,3-dihydro-1H-inden-2-yl)acetamide and has the molecular formula of C12H13NO. It is part of indanes, which are organic compounds containing an indane moiety, which is a monocyclic saturated hydrocarbon ring of five carbon atoms and one hydrogen atom. It's commonly used in scientific research with various chemical and physical properties. Detailed specifications, including isomeric structure, molecular weight, and other properties may vary depending on the context of its use and production procedure.

InChI:InChI=1/C11H13NO/c1-8(13)12-11-6-9-4-2-3-5-10(9)7-11/h2-5,11H,6-7H2,1H3,(H,12,13)

Upstream product

• 2338-18-3 2-aminoindane hydrochloride 
• 75-36-5 acetyl chloride 
• 108-22-5 Isopropenyl acetate 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 
• 108-24-7 acetic anhydride 

Downstream Products

• 312753-53-0 5,6-diethyl-2,3-dihydro-1H-inden-2-amine hydrochloride 
• 1286264-40-1 N²-[5-chloro-2-(4-chlorophenoxy)phenyl]-N²-{2-[2,3-dihydro-1H-inden-2-yl(ethyl)amino]-2-oxoethyl}-N¹-(2-pyrrolidin-1-ylethyl)glycinamide 
• 53545-51-0 N-ethylindan-2-amine hydrochloride 
• 1345688-35-8 N-(5-{4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl}-2,3-dihydro-1H-inden-2-yl)acetamide 
• 31952-21-3 2-(2,3-dihydro-1H-inden-2-yl)-1H-isoindole-1,3(2H)-dione 
• 153731-73-8 2-(((4-chlorophenyl)sulfonyl)amino)indan-5-yl 3-pyridyl ketone 

Relevant articles and documents

Glycinamide derivative as well as preparation method and application thereof

The invention discloses a glycinamide derivative as well as a preparation method and application thereof. The derivative with a structural formula as shown in the following formula (I) is provided; and in the formula, R1 is selected from Cl and H, R2 is one selected from H, CH3 and CH2CH3; and X is one selected from NHCH3, NHCH2CH3, N (CH2CH3) 2, a pyrrolyl group and a piperidyl group. During preparation, different phenyl glutaric acid compounds are selected as raw materials and are respectively subjected to amidation reaction twice with an aminoindane hydrochloride derivative and an ethylenediamine derivative to obtain a target derivative. The prepared derivative or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition thereof can be used as an S-adenosyl homocysteine hydrolase inhibitor for the development of antitumor drugs .

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

Malaria persists as one of the most devastating global infectious diseases. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) has been identified as a new malaria drug target, and a triazolopyrimidine-based DHODH inhibitor 1 (DSM265) is in clinical development. We sought to identify compounds with higher potency against Plasmodium DHODH while showing greater selectivity toward animal DHODHs. Herein we describe a series of novel triazolopyrimidines wherein the p-SF5-aniline was replaced with substituted 1,2,3,4-tetrahydro-2-naphthyl or 2-indanyl amines. These compounds showed strong species selectivity, and several highly potent tetrahydro-2-naphthyl derivatives were identified. Compounds with halogen substitutions displayed sustained plasma levels after oral dosing in rodents leading to efficacy in the P. falciparum SCID mouse malaria model. These data suggest that tetrahydro-2-naphthyl derivatives have the potential to be efficacious for the treatment of malaria, but due to higher metabolic clearance than 1, they most likely would need to be part of a multidose regimen.

Green synthesis of benzamides in solvent- and activation-free conditions

Herein, we describe a clean and ecocompatible pathway for both N-benzoylation and N-acetylation of anilines, amines, diamines, and aminoalcohols using three enol esters with good yields. We have improved the use of vinyl benzoate for the direct introduction of a benzamido-moiety under solvent- and activation-free conditions. The recovered amides are easily isolated by crystallization. Copyright