1394290-75-5

Basic information

• Product Name: methyl 4-(4,4,4-trifluorobut-1-ynyl)benzoate
• Synonyms: methyl 4-(4,4,4-trifluorobut-1-ynyl)benzoate
• CAS NO: 1394290-75-5
• Molecular Weight: 242.197
• Mol File: 1394290-75-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 4-(4,4,4-trifluorobut-1-ynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4,4,4-trifluorobut-1-ynyl)benzoate(1394290-75-5)
• EPA Substance Registry System: methyl 4-(4,4,4-trifluorobut-1-ynyl)benzoate(1394290-75-5)

Safety Data

• Hazardous Substances Data: 1394290-75-5(Hazardous Substances Data)

Upstream product

• 421-06-7 2-bromo-1,1,1-trifluoroethane 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 1357155-90-8 3-((4-methoxycarbonyl)phenyl) propiolic acid 
• 75867-41-3 4-trimethylsilanylethynyl-benzoic acid methyl ester 
• 619-44-3 methyl 4-iodobenzoate 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 3034-86-4 4-ethynylbenzoic acid methyl ester 

Relevant articles and documents

Method for preparing trifluoro-ethyl phenylacetylene compound

The invention provides a method for preparing a trifluoro-ethyl phenylacetylene compound. The method comprises the following step: in the presence of a copper catalyst, alkali and ligand, enabling potassium alkynyl trifluoroborate and tribromofluoroethane to react in a solvent, thereby obtaining the trifluoro-ethyl phenylacetylene compound. The method provided by the invention is capable of achieving high-yield synthesis of the trifluoro-ethyl phenylacetylene compound, and has good application prospects and industrial production potential.

Palladium-catalyzed trifluoroethylation of terminal alkynes with 1,1,1-trifluoro-2-iodoethane

An efficient Csp-CH2CF3 bond-forming reaction via Pd-catalyzed 2,2,2-trifluoroethylation of aryl and alkyl terminal alkynes has been developed. This protocol proceeds under mild conditions using the readily available and cheap reagent CF3CH2I as the source of the CH2CF3 group. Various terminal aryl alkynes as well as alkylacetylenes can be transformed into the corresponding trifluoroethylated products in good-to-excellent yields. The method is tolerant of carbonyl, nitro, ester, cyano, and even formyl groups.