1394837-92-3Relevant articles and documents
Iodine-125-terbutaline (125ITB): A new β2- adrenoceptor probe for lung imaging
Amin
, p. 289 - 295 (2012)
Development of a selective β2-adrenoceptor tracer for single photon emission tomography is important for imaging of the lungs. Iodine-125-terbutaline (125ITB) was prepared by the reaction of terbutaline with iodine-125 in the presence of chloramine-T as the oxidizing agent. The reaction was completed by incubation of the reaction mixture at 70°C for 15 minutes at pH 7. The biodistribution study in mice indicated the ability of the tracer to bind β-adrenoceptors in lungs, liver, heart, and spleen. The localization of the tracer in the lungs was high (85%/g at 60 minutes post-injection) and the highest lung/blood/g ratio was 19.8% at 60 minutes post-injection. The selectivity of the tracer for the β2-adrenoceptor was examined by blocking with both β1 and β2-adrenoceptor selective antagonists. The results showed reduction of both heart and lung uptake of the 125ITB tracer, indicating a moderate (not absolute) selectivity for the β2-adrenoceptor. Copyright
