139524-57-5Relevant articles and documents
HETEROCYCLIC COMPOUND
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Page/Page column 62, (2013/02/28)
Provided is a compound useful for the prophylaxis or treatment of cancer. The present invention relates to a compound represented by formula (I): wherein each symbol in the formula is as defined in the specification, or a salt thereof or a prodrug thereof, which is useful for the prophylaxis or treatment of cancer.
HIV Integrase Inhibitors
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Page/Page column 34, (2010/11/29)
The invention encompasses series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
Preparation and in Vitro and in Vivo Evaluation of Quinolones with Selective Activity against Gram-Positive Organisms
Cooper, Curt S.,Klock, Pamela L.,Chu, Daniel T. W.,Hardy, Dwight J.,Swanson, Robert N.,Plattner, Jacob J.
, p. 1393 - 1398 (2007/10/02)
A series of quinolones were prepared which contained oximes or substituted oximes as replacements for the amine substituents normally found on the pyrrolidine or piperidine fragments of quinolone antibacterial agents.These substituents led to compounds that had selective activity against Gram-positive organisms.These compounds showed in vivo activity Staphylococcus aureus.Only compound 29 had in vivo activity against Streptococcus pneumoniae.