1398179-24-2

Basic information

• Product Name: ethyl 2-(2-bromophenyl)-2-diazoacetate
• Synonyms: ethyl 2-(2-bromophenyl)-2-diazoacetate
• CAS NO: 1398179-24-2
• Molecular Weight: 269.098
• Mol File: 1398179-24-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-bromophenyl)-2-diazoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-bromophenyl)-2-diazoacetate(1398179-24-2)
• EPA Substance Registry System: ethyl 2-(2-bromophenyl)-2-diazoacetate(1398179-24-2)

Safety Data

• Hazardous Substances Data: 1398179-24-2(Hazardous Substances Data)

Upstream product

• 2178-24-7 ethyl 2-(2-bromophenyl)ethanoate 
• 108-86-1 bromobenzene 

Downstream Products

• 1398180-70-5 ethyl 2-(2-bromophenyl)-3,3,3-trifluoropropanoate 
• 92-52-4 biphenyl 

Relevant articles and documents

(HETERO)ARYL-METHYL-THIO-BETA-D-GALACTOPYRANOSIDE DERIVATIVES

The present invention relates to compounds of Formula (I) wherein Ar1, Ar2, R1a, R1b, and R2 are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as Galectin-3 inhibitors.

Three-Component Ring-Opening Reactions of Cyclic Ethers, α-Diazo Esters, and Weak Nucleophiles under Metal-Free Conditions

A protocol for three-component reactions of cyclic ethers, α-diazo esters, and weak nitrogen, oxygen, carbon, and sulfur nucleophiles (pKa = 2.2-14.8) to afford a variety of structurally complex α-oxyalkylated esters is reported. These reactions involve intermolecular activation of the cyclic ether (present in excess) by the α-diazo ester to form an oxonium ylide under metal-free conditions, followed by ring opening by the nucleophile.

Silver-mediated direct trifluoromethoxylation of α-diazo esters: Via the -OCF3 anion

Silver-mediated direct trifluoromethoxylation of α-diazo esters and ketosteroid was disclosed. The reactions of alkyl α-diazo arylacetates with AgOCF3 or CF3SO2OCF3/AgF at -30 to 10 °C under a N2 atmosphere provided α-trifluoromethoxyl arylacetates in up to 90% yield, while alkyl α-diazo vinylacetates reacting with CF3SO2OCF3/AgF or AgOCF3 afforded γ-trifluoromethoxyl α,β-unsaturated esters in up to 94% yield. The α-diazo ketosteroid was also trifluoromethoxylated under the standard reaction conditions. This protocol allows for an effective and convenient access to a large number of synthetic building blocks, which are promising in the development of new functional OCF3-molecules.