139993-81-0

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 4-(4-fluorophenyl)-2-(1-methylethyl)-, ethyl ester
• CAS NO: 139993-81-0
• Molecular Formula: C16H18FNO2
• Molecular Weight: 275.323
• Mol File: 139993-81-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 4-(4-fluorophenyl)-2-(1-methylethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 4-(4-fluorophenyl)-2-(1-methylethyl)-, ethyl ester(139993-81-0)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 4-(4-fluorophenyl)-2-(1-methylethyl)-, ethyl ester(139993-81-0)

Safety Data

• Hazardous Substances Data: 139993-81-0(Hazardous Substances Data)

Upstream product

• 456-00-8 2-amino-4'-fluoroacetophenone hydrochloride 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 

Relevant articles and documents

Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors

A novel series of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates were synthesized and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. Monocalcium bis(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methanesulfonylaminopyrimidin)-5-yl]-(3R,5S)-dihydroxy- (E)-6-heptenoate (3a, S-4522) was selected as a candidate for further evaluation. Compound 3a was approximately four times more potent than lovastatin sodium salt (in inhibiting HMG-CoA reductase in vitro (IC50 = 11 nM). Compound 3a was shown to be the most potent cholesterol biosynthesis inhibitor in this series (IC50 = 1.12 nM) in rat isolated hepatocytes; its inhibitory activity was approximately 100 times more potent than pravastatin.