141190-94-5Relevant articles and documents
Enantioselective syntheses of α-, β-, and γ-aryl amino acids and esters
Park, Yong Sun,Beak, Peter
, p. 1574 - 1575 (1997)
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Nitrogen-Doped Carbon Enables Heterogeneous Asymmetric Insertion of Carbenoids into Amines Catalyzed by Rhodium Nanoparticles
Kobayashi, Shū,Masuda, Ryusuke,Yamashita, Yasuhiro,Yasukawa, Tomohiro
supporting information, p. 12786 - 12790 (2021/05/07)
Development of stable heterogeneous catalyst systems is a crucial subject to achieve sustainable society. Though metal nanoparticles are robust species, the study of asymmetric catalysis by them has been restricted because methods to activate metal nanopa
Synthesis of α-amino acid derivatives and peptides via enantioselective addition of masked acyl cyanides to imines
Yang, Kin S.,Rawal, Viresh H.
supporting information, p. 16148 - 16151 (2015/02/02)
A general, asymmetric synthesis of amino acid derivatives is reported. Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective additions to N-Boc-aldimines. The reactions are catalyzed by a modified cinchona alkaloid, which can function as a bifunctional, hydrogen bonding catalyst, and afford adducts in excellent yields (90-98%) and high enantioselectivities (up to 97.5:2.5 er). Unmasking the addition products gives acyl cyanide intermediates that are intercepted by a variety of nucleophiles to afford α-amino acid derivatives. Notably, the methodology provides an alternative method for peptide bond formation.
OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF
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Paragraph 0429-0430, (2013/09/26)
Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
