1412776-10-3

Basic information

• Product Name: N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl) phenyl)-5-fluoro-2-methylbenzenesulfonamide
• Synonyms: N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl) phenyl)-5-fluoro-2-methylbenzenesulfonamide
• CAS NO: 1412776-10-3
• Molecular Weight: 511.574
• Mol File: 1412776-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl) phenyl)-5-fluoro-2-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl) phenyl)-5-fluoro-2-methylbenzenesulfonamide(1412776-10-3)
• EPA Substance Registry System: N-(4-(1-acetyl-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-5-yl) phenyl)-5-fluoro-2-methylbenzenesulfonamide(1412776-10-3)

Safety Data

• Hazardous Substances Data: 1412776-10-3(Hazardous Substances Data)

Upstream product

• 130671-93-1 BG₀₄₀₂ 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 555-16-8 4-nitrobenzaldehdye 
• 1412774-73-2 1-(5-(4-aminophenyl)-3-(3,4-dimethoxyphenyl)-4, 5-dihydro-1H-pyrazol-1-yl)ethanone 
• 445-05-6 5-fluoro-2-methylbenzenesulfonyl chloride 
• 1412774-67-4 1-(3-(3,4-dimethoxyphenyl)-5-(4-nitrophenyl)-4, 5-dihydro-1H-pyrazol-1-yl)ethanone 

Relevant articles and documents

Synthesis, anti-inflammatory and antimicrobial evaluation of novel 1-acetyl-3,5-diaryl-4,5-dihydro (1H) pyrazole derivatives bearing urea, thiourea and sulfonamide moieties

A series of novel 1-acetyl-3-(3,4-dimethoxypheny)-5-(4-(3-(arylureido/ arylthioureido/arylsulfonamido) phenyl)-4,5-dihydropyrazole derivatives of biological interest have been prepared by sequential cyclization of 1-(4-nitrophenyl)-3-(3,4-dimethoxyphenyl)-pro-2-ene-1 with hydrazine hydrate, reduction followed by reaction of resulting amine with different arylisocyanates or arylisothiocyanates or arylsulfonyl chlorides. All the synthesized compounds (1-32) have been screened for their pro-inflammatory cytokines (TNF-α and IL-6) and antimicrobial activity (antibacterial and antifungal). Biological evaluation study showed, the compounds 4, 5, 9, 11, 14 and 16 found to have promising anti-inflammatory activity (up to 61-85% TNF-α and 76-93% IL-6 inhibitory activity) at concentration of 10 μM with reference to standard dexamethasone (76% TNF-α and 86% IL-6 inhibitory activity at 1 μM). Compounds 24, 26, 27, 28 and 29 exhibited promising antimicrobial activity at MIC values ranging from 70 to 10 μg/mL against all the selected pathogenic bacteria and fungi.