141410-06-2 Usage
Description
1H-Indole-2-carboxylic acid, 2,3-dihydro-, methyl ester, (2S)-(9CI) is a chiral indole derivative featuring a 2,3-dihydro-indole ring with a carboxylic acid group and a methyl ester functional group. 1H-Indole-2-carboxylicacid,2,3-dihydro-,methylester,(2S)-(9CI) is characterized by its (2S) configuration, which denotes the positioning of the methyl ester group on the second carbon of the indole ring. It is a versatile chemical entity with potential applications in pharmaceuticals and organic synthesis.
Uses
Used in Pharmaceutical Synthesis:
1H-Indole-2-carboxylic acid, 2,3-dihydro-, methyl ester, (2S)-(9CI) is utilized as a key intermediate in the synthesis of various pharmaceutical drugs. Its unique molecular structure and chirality make it a valuable component in the development of new medications with specific therapeutic targets.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Indole-2-carboxylic acid, 2,3-dihydro-, methyl ester, (2S)-(9CI) serves as a building block for the creation of more complex organic molecules. Its reactivity and structural features facilitate its incorporation into a wide range of chemical products, contributing to the advancement of material science and specialty chemicals.
Used in Research and Development:
Due to its potential biological activity and distinctive structural attributes, 1H-Indole-2-carboxylic acid, 2,3-dihydro-, methyl ester, (2S)-(9CI) is of interest in research and development endeavors. It may be employed in studies aimed at understanding its interactions with biological systems, leading to the discovery of novel applications in medicine and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 141410-06-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,4,1 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 141410-06:
(8*1)+(7*4)+(6*1)+(5*4)+(4*1)+(3*0)+(2*0)+(1*6)=72
72 % 10 = 2
So 141410-06-2 is a valid CAS Registry Number.
141410-06-2Relevant articles and documents
A Proline Mimetic for the Design of New Stable Secondary Structures: Solvent-Dependent Amide Bond Isomerization of (S)-Indoline-2-carboxylic Acid Derivatives
Pollastrini, Matteo,Lipparini, Filippo,Pasquinelli, Luca,Balzano, Federica,Barretta, Gloria Uccello,Pescitelli, Gennaro,Angelici, Gaetano
, p. 7946 - 7954 (2021/06/28)
A thorough experimental and computational study on the conformational properties of (S)-indoline-2-carboxylic acid derivatives has been conducted. Methyl (S)-1-acetylindoline-2-carboxylate, both a mimetic of proline and phenylalanine, shows a remarkable tendency toward the cis amide isomer when dissolved in polar solvents. This behavior is opposite to the general preference of proline for the trans isomer, making indoline-2-carboxylic acid a good candidate for the design of different secondary structures and new materials.
Asymmetric Counteranion Directed Catalytic Heck/Tsuji-Trost Annulation of Aryl Iodides and 1,3-Dienes
Xu, Jia-Cheng,Yin, Yi-Zhuo,Han, Zhi-Yong
supporting information, p. 3834 - 3838 (2021/05/26)
A chiral anion-mediated asymmetric Heck/Tsuji-Trost reaction of aryl iodides and 1,3-dienes is presented. Chiral indoline derivatives could be afforded with remarkably higher yields and enantioselectivities than our previous chiral ligand-based method. Silver carbonate is employed as both base and halide scavenger to ensure fast and recyclable exchange of the catalytic amount of chiral anions. Fast salt metathesis, as well as the acceleration effect of the chiral anion, could both benefit the stereocontrol of the reaction.
Enantioselective Reformatsky Reaction of Ketones Catalyzed by Chiral Indolinylmethanol
Luo, Renshi,Chen, Miao-Miao,Ouyang, Lu,Chan, Albert S. C.,Lu, Gui
supporting information, p. 4805 - 4811 (2020/07/14)
A reliable and practical Reformatsky reaction of ethyl iodide acetate with ketones for the synthesis of chiral β-hydroxyl carbonyl compounds in good yields and excellent enantioselectivities is presented. A readily available dihydroindole derivative was u