1416711-53-9Relevant articles and documents
Synthesis method of paraben compounds marked by stable isotope 13C or D
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Paragraph 0037; 0038, (2017/02/28)
The invention relates to a synthesis method of paraben compounds marked by a stable isotope 13C or D. In the method, p-hydroxybenzoic acid, which is marked by the stable isotope 13C or D, and an alcohol compound are employed as raw materials for preparing the paraben compounds under the effect of an acidic catalyst p-toluenesulfonic acid. Compared with a synthesis process of the paraben compounds in natural abundance, the method is free of isotope dilution during the reaction process, has mild reaction conditions and high utilization rate on the isotopes. The paraben compounds marked by the stable isotope 13C or D, after separation and purification, are more than 99% in chemical purity and are more than 99 atom% in isotope abundance.