14213-19-5

Basic information

• Product Name: Cyanamide, (4-fluorophenyl)-
• Synonyms: 4-Fluoro-phenyl-cyanamide;p-Fluorphenylcyanamid;4-fluorophenylcyanamide;4-Fluorphenylcyanamid;(4-fluorophenyl)cyanamide;p-fluorophenylcyanamide
• CAS NO: 14213-19-5
• Molecular Formula: C7H5FN2
• Molecular Weight: 136.129
• Mol File: 14213-19-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 189.3±42.0 °C(Predicted)
• Density: 1.278±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Cyanamide, (4-fluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyanamide, (4-fluorophenyl)-(14213-19-5)
• EPA Substance Registry System: Cyanamide, (4-fluorophenyl)-(14213-19-5)

Safety Data

• Hazardous Substances Data: 14213-19-5(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 459-23-4 4-fluorobenzaldoxime 
• 420-04-2 CYANAMID 
• 352-34-1 4-fluoro-1-iodobenzene 
• 371-40-4 4-fluoroaniline 
• 506-68-3 bromocyane 
• 1194-02-1 4-fluorobenzonitrile 
• 22179-78-8 4-fluoro-benzamidoxime 
• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 1544-68-9 4-fluorophenyl isothiocyanate 

Downstream Products

• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 1414382-25-4 1-(4-fluorophenyl)-5-methyl thiohydantoin 
• 1345028-80-9 C₁₁H₁₁FN₂O₂ 
• 18201-87-1 2-[(4-fluorophenyl)amino]benzonitrile 
• 30895-14-8 1-(4-fluorophenyl)-1H-tetrazol-5-amine 
• 1046786-81-5 N-(4-fluorolphenyl)-2-oxo-2-phenylacetamide 

Relevant articles and documents

Iron-mediated desulphurization approach: synthesis of cyanamides and their conversions

The iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology. All the reactions are rapid, facile, and accomplished at room temperature. A variety of substrates readily underwent the optimized reaction conditions to provide their respective target products in good to excellent yields. Furthermore, we have confirmed that no other by-products could be identified during our experimental reaction process. Graphical abstract: Iron-mediated efficient multi-component method has been demonstrated for the synthesis of substituted cyanamides from isothiocyanates under mild reaction conditions. Subsequent nucleophilic addition and desulfurization are involved in this proposed synthetic methodology.[Figure not available: see fulltext.].

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

Cobalt-promoted one-pot reaction of isothiocyanates toward the synthesis of aryl/alkylcyanamides and substituted tetrazoles

[Figure not available: see fulltext.] The synthesis of cyanamides and tetrazoles from isothiocyanates through tandem reaction using cobalt catalyst has been demonstrated. In the case of tetrazole preparation, the reaction involved addition/desulfurization/nucleophilic addition/electrocyclization, whereas aromatic cyanamides were constructed from isothiocyanates through addition/desulfurization. Cheap cobalt sulfate was used for the synthesis of various cyanamides and tetrazoles. In addition, cobalt catalyst was found to be desulfurization reagent that has not been previously reported. The final products have been obtained from starting precursors in good to high yield.