1422984-99-3Relevant articles and documents
3-nitro-2-phenyl-2-(Trifluoromethyl)-2h-chromenes: Synthesis and reactions with nucleophiles
Barkov, Alexey Yu.,Korotaev, Vladislav Yu.,Kotovich, Ivan V.,Zimnitskiy, Nikolai S.,Kutyashev, Igor B.,Sosnovskikh, Vyacheslav Ya.
, p. 814 - 822 (2016)
A method is proposed for the synthesis of 3-nitro-2-phenyl-2-(trifluoromethyl)-2H-chromenes by tandem condensation of salicylic aldehydes with (E)-3,3,3-trifluoro-1-nitro-2-phenylprop-1-ene in the presence of triethylamine. The example of 3-nitro-2-phenyl
Access to Chiral GABA Analogues Bearing a Trifluoromethylated All-Carbon Quaternary Stereogenic Center through Water-Promoted Organocatalytic Michael Reactions
Sim, Jae Hun,Park, Jin Hyun,Maity, Pintu,Song, Choong Eui
supporting information, p. 6715 - 6719 (2019/10/02)
Water enables the highly challenging enantioselective Michael addition of sterically congested β-trifluoromethyl-β-aryl- or -alkyl-substituted nitroolefins with dithiomalonates. Under on-water conditions, the reaction rates were remarkably accelerated as
Enantioselective Michael Addition of Pyrazolin-5-ones to β-CF3-β-Disubstituted Nitroalkenes Catalyzed by Squaramide Organocatalyst
Lai, Xiaoyan,Zha, Gaofeng,Liu, Wei,Xu, Yan,Sun, Panpan,Xia, Tao,Shen, Yongcun
supporting information, p. 1983 - 1988 (2016/08/09)
A highly enantioselective Michael addition of pyrazolin-5-ones with β-CF3-β-disubstituted nitroalkenes catalyzed by bifunctional squaramide has been developed. Various chiral β-CF3-β-5-hydroxy-pyrazolin-3-yl-disubstituted nitroalkane derivatives bearing all-carbon quaternary stereocenter were prepared in good yields (up to 88%) and excellent enantioselectivities (up to 97% ee).