1422985-26-9

Basic information

• Product Name: 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole
• Synonyms: 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole
• CAS NO: 1422985-26-9
• Molecular Weight: 368.743
• Mol File: 1422985-26-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole(1422985-26-9)
• EPA Substance Registry System: 3-(2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-yl)-1H-indole(1422985-26-9)

Safety Data

• Hazardous Substances Data: 1422985-26-9(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 104-88-1 4-chlorobenzaldehyde 
• 72487-06-0 1-(4-chlorophenyl)-2,2,2-trifluoroethanol 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 1422984-88-0 2-(4-chlorophenyl)-1,1,1-trifluoro-3-nitropropan-2-ol 
• 1422985-07-6 (E)-1-chloro-4-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)benzene 

Relevant articles and documents

Highly enantioselective construction of CF3-bearing all-carbon quaternary stereocenters: Hiral spiro-fused bisoxazoline ligands with 1,1′-binaphthyl sidearm for asymmetric Michael-type Friedel-Crafts reaction

A novel class of chiral spiro-fused bisoxazoline ligands possessing a deep chiral pocket was prepared. The developed ligands have been employed in the nickel-catalyzed highly enantioselective Michael-type Friedel-Crafts reaction, affording the products bearing a trifluoromethylated all-carbon quaternary stereocenter with moderate to excellent yields (up to 99%) and good to excellent enantioselectivies (up to > 99.9% ee). Moreover, a proposed model of chiral pocket revealed that the attack of indole from the Re-face of β-CF3-β-disubstituted nitroalkene was favorable.