142650-77-9

Basic information

• Product Name: 3-(1-adamantyl)-4-methoxyphenol
• Synonyms: 3-(1-adamantyl)-4-methoxyphenol
• CAS NO: 142650-77-9
• Molecular Weight: 258.36
• Mol File: 142650-77-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(1-adamantyl)-4-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-adamantyl)-4-methoxyphenol(142650-77-9)
• EPA Substance Registry System: 3-(1-adamantyl)-4-methoxyphenol(142650-77-9)

Safety Data

• Hazardous Substances Data: 142650-77-9(Hazardous Substances Data)

Upstream product

• 121-43-7 Trimethyl borate 
• 104224-63-7 2-(1-adamantyl)-4-bromoanisole 
• 108-95-2 phenol 
• 768-95-6 1-adamanthanol 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 191934-12-0 methyl 2-[3-(1-adamantyl)-4-methoxyphenoxymethyl]-4-thiophenecarboxylate 
• 191933-78-5 O-3-(1-adamantyl)-4-methoxyphenyl dimethylthiocarbamate 

Relevant articles and documents

Ion-exchange-resin-catalyzed adamantylation of phenol derivatives with adamantanols: Developing a clean process for synthesis of 2-(1-adamantyl)-4- bromophenol, A key intermediate of adapalene

A clean process has been developed for the synthesis of 2-adamantylphenol derivatives through adamantylation of substituted phenols with adamantanols catalyzed by commercially available and recyclable ion-exchange sulfonic acid resin in acetic acid.The sole byproduct of the adamantylation reaction,namely water,could be converted into the solvent acetic acid by addition of a slight excess of acetic anhydride during the work-up procedure,making the process waste-free except for regeneration of the ionexchange resin,and facilitating the recycling of the resin catalyst.The ion-exchange sulfonic acid resin catalyst could be readily recycled by filtration and directly reused at least ten times without a significant loss of activity.The key intermediate of adapalene,2-(1-adamantyl)-4-bromophenol,could be produced by means of this waste-free process.