1426551-45-2

Basic information

• Product Name: N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
• Synonyms: N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
• CAS NO: 1426551-45-2
• Molecular Weight: 369.461
• Mol File: 1426551-45-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide(1426551-45-2)
• EPA Substance Registry System: N-(4-(hydroxymethyl)phenyl)-N,3-dimethyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide(1426551-45-2)

Safety Data

• Hazardous Substances Data: 1426551-45-2(Hazardous Substances Data)

Upstream product

• 131230-76-7 4-[(tert-butyldimethylsilyloxy)methyl]aniline 
• 623-04-1 4-aminobenzenemethanol 
• 84945-01-7 3,4-dihydro-6-hydroxy-4,4,7,8-tetramethyl-1(2H)-benzopyran-2-one 
• 40662-29-1 3-methyl-3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid 
• 181819-75-0 (4-(methylamino)phenyl)methanol 
• 541-47-9 3-Methylbutenoic acid 
• 700-13-0 Trimethylhydroquinone 
• 40662-76-8 6-hydroxy-4,4,5,7,8-pentamethyl-3,4-dihydrocoumarin 
• 1609626-96-1 C₂₈H₄₁NO₄Si 
• 1254102-47-0 4-((tert-butyldimethylsilyloxy)-N-methylamino)benzyl alcohol 

Downstream Products

• 1609626-97-2 C₃₉H₄₁N₃O₇ 

Relevant articles and documents

Rational designed highly sensitive NQO1-activated near-infrared fluorescent probe combined with NQO1 substrates in vivo: An innovative strategy for NQO1-overexpressing cancer theranostics

Since NQO1 is overexpressed in many cancer cells, it can be used as a biomarker for cancer diagnosis and targeted therapy. NQO1 substrates show potent anticancer activity through the redox cycle mediated by NQO1, while the NQO1 probes can monitor NQO1 levels in cancers. High sensitivity of probes is needed for diagnostic imaging in clinic. In this study, based on the analysis of NQO1 catalytic pocket, the naphthoquinone trigger group 13 rationally designed by expanding the aromatic plane of the benzoquinone trigger group 10 shows significantly increased sensitivity to NQO1. The sensitivity of the naphthoquinone trigger group-based probe A was eight times higher than that of benzoquinone trigger group-based probe B in vivo. Probe A was selectively and efficiently sensitive to NQO1 with good safety profile and plasma stability, enabling its combination with NQO1 substrates in vivo for NQO1-overexpressing cancer theranostics for the first time.

An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5-Fluorouracil for Safe and Effective Cancer Therapy

Tripartite prodrug 1, composed of an NAD(P)H:quinone oxidoreductase 1 (NQO1)-responsive trigger group, a self-immolative linker, and the active drug 5-fluorouracil (5-FU), was designed and synthesized for site-specific cancer therapy. Upon bioreductive ac

COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H

The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox defining co-factor NAD(P)/NAD(P)H measurement.