142955-69-9Relevant articles and documents
Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni
Pereira, Vinicius R.D.,da Silveira, Lígia S.,Mengarda, Ana C.,Alves Júnior, Ismael J.,da Silva, Ohana Oliveira Zuza,Miguel, Fábio Balbino,Silva, Marcos P.,Almeida, Ayla das C.,Torres, Daniel da Silva,Pinto, Priscila de F.,Coimbra, Elaine S.,de Moraes, Josué,Couri, Mara R.C.,da Silva Filho, Ademar A.
, (2020/11/17)
Schistosomiasis is a neglected disease caused by helminth flatworms of the genus Schistosoma, affecting over 240 million people in more than 70 countries. The treatment relies on a single drug, praziquantel, making urgent the discovery of new compounds. A
In Vitro and in Vivo Antischistosomal Activities of Chalcones
Pereira, Vinícius R. D.,Junior, Ismael J. Alves,da Silveira, Lígia S.,Geraldo, Reinaldo B.,de F. Pinto, Priscila,Teixeira, Fernanda S.,Salvadori, Maria C.,Silva, Marcos P.,Alves, Lara A.,Capriles, Priscila V. S. Z.,das C. Almeida, Ayla,Coimbra, Elaine S.,Pinto, Pedro L. S.,Couri, Mara R. C.,de Moraes, Josué,Da Silva Filho, Ademar A.
, (2019/01/04)
In this study, we evaluated the in vitro and in vivo schistosomicidal activities of chalcones against Schistosoma mansoni worms. In vitro assays revealed that chalcones 1 and 3 were the most active compounds, without affecting significantly mammalian cells. Confocal laser scanning microscopy and scanning electron microscopy studies revealed reduction on the numbers of tubercles and morphological alterations in the tegument of S. mansoni worms after in vitro incubation with chalcones 1 and 3. In a mouse model of schistosomiasis, the oral treatment (400 mg/kg) with chalcone 1 or 3 significantly caused a total worm burden reduction in mice. Chalcone 1 showed significant inhibition of the S. mansoni ATP diphosphohydrolase activity, which was corroborated by molecular docking studies. The results suggested that chalcones could be explored as lead compounds with antischistosomal properties.
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Borsari, Chiara,Santarem, Nuno,Torrado, Juan,Olías, Ana Isabel,Corral, María Jesús,Baptista, Catarina,Gul, Sheraz,Wolf, Markus,Kuzikov, Maria,Ellinger, Bernhard,Witt, Gesa,Gribbon, Philip,Reinshagen, Jeanette,Linciano, Pasquale,Tait, Annalisa,Costantino, Luca,Freitas-Junior, Lucio H.,Moraes, Carolina B.,Bruno dos Santos, Pascoalino,Alcantara, Laura Maria,Franco, Caio Haddad,Bertolacini, Claudia Danielli,Fontana, Vanessa,Tejera Nevado, Paloma,Clos, Joachim,Alunda, José María,Cordeiro-da-Silva, Anabela,Ferrari, Stefania,Costi, Maria Paola
supporting information, p. 1129 - 1135 (2017/01/12)
Chalcones display a broad spectrum of pharmacological activities. Herein, a series of 2’-hydroxy methoxylated chalcones was synthesized and evaluated towards Trypanosoma brucei, Trypanosoma cruzi and Leishmania infantum. Among the synthesized library, com
