1429658-37-6Relevant articles and documents
Inhibiting NF-κB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures
Li, Kexue,McGee, Lawrence R.,Fisher, Ben,Sudom, Athena,Liu, Jinsong,Rubenstein, Steven M.,Anwer, Mohmed K.,Cushing, Timothy D.,Shin, Youngsook,Ayres, Merrill,Lee, Fei,Eksterowicz, John,Faulder, Paul,Waszkowycz, Bohdan,Plotnikova, Olga,Farrelly, Ellyn,Xiao, Shou-Hua,Chen, Guoqing,Wang, Zhulun
, p. 1238 - 1244 (2013)
The discovery, structure-based design, synthesis, and optimization of NIK inhibitors are described. Our work began with an HTS hit, imidazopyridinyl pyrimidinamine 1. We utilized homology modeling and conformational analysis to optimize the indole scaffol
