1430423-86-1

Basic information

• Product Name: (1-fluoropropane-1,3-diyl)dibenzene
• Synonyms: (1-fluoropropane-1,3-diyl)dibenzene
• CAS NO: 1430423-86-1
• Molecular Weight: 214.283
• Mol File: 1430423-86-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1-fluoropropane-1,3-diyl)dibenzene(CAS DataBase Reference)
• NIST Chemistry Reference: (1-fluoropropane-1,3-diyl)dibenzene(1430423-86-1)
• EPA Substance Registry System: (1-fluoropropane-1,3-diyl)dibenzene(1430423-86-1)

Safety Data

• Hazardous Substances Data: 1430423-86-1(Hazardous Substances Data)

Upstream product

• 14097-24-6 1,3-diphenylpropan-1-ol 
• 100-42-5 styrene 
• 13005-36-2 potassium phenylacetate 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 1081-75-0 1,3-diphenylpropane 

Relevant articles and documents

Deoxyfluorination with CuF2: Enabled by Using a Lewis Base Activating Group

Deoxyfluorination is a primary method for the formation of C?F bonds. Bespoke reagents are commonly used because of issues associated with the low reactivity of metal fluorides. Reported here is the development of a simple strategy for deoxyfluorination, using first-row transition-metal fluorides, and it overcomes these limitations. Using CuF2 as an exemplar, activation of an O-alkylisourea adduct, formed in situ, allows effective nucleophilic fluoride transfer to a range of primary and secondary alcohols. Spectroscopic investigations have been used to probe the origin of the enhanced reactivity of CuF2. The utility of the process in enabling 18F-radiolabeling is also presented.

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation

A combinatorial nickel-catalyzed monofluoroalkylation of aryl halides with unactivated fluoroalkyl halides by reductive cross-coupling has been developed. This method demonstrated high efficiency, mild conditions, and excellent functional-group tolerance, thus enabling the late-stage monofluoroalkylation of diverse drugs. The key to success was the combination of diverse readily available bidentate and monodentate pyridine-type nitrogen ligands with nickel, which in situ generated a variety of readily tunable catalysts to promote fluoroalkylation with broad scope with respect to both coupling partners. This combinatorial catalysis strategy offers a solution for nickel-catalyzed reductive cross-coupling reactions and provides an efficient way to synthesize fluoroalkylated druglike molecules for drug discovery.

Metal-free fluorination of C(sp3)-H bonds using a catalytic N-oxyl radical

A direct conversion of C(sp3)-H bonds to C(sp3)-F bonds has been developed. In this process, a catalytic N-oxyl radical generated from N,N-dihydroxypyromellitimide abstracts hydrogen from the C(sp 3)-H bond and Selectfluor acts to trap the resulting carbon radical to form the C(sp3)-F bond. This simple metal-free protocol enables the chemoselective introduction of a fluorine atom into various aromatic and aliphatic compounds and serves as a powerful tool for the efficient synthesis of fluorinated molecules.