1435-51-4

Basic information

• Product Name: 1,3-Dibromo-5-fluorobenzene
• Synonyms: 3,5-DIBROMOFLUOROBENZENE;1,3-DIBROMO-5-FLUOROBENZENE;3,5-Dibromo-1-fluorobenzene;1,3-Dibromo-5-fluorobenzene 98%;1,3-Dibromo-5-fluorobenzene98%;1,3-Dibromo-5-fluoro;3,5-Dibromofluorobenzene 98%;3,5-Bromo-1-fluorophenyl
• CAS NO: 1435-51-4
• Molecular Formula: C₆H₃Br₂F
• Molecular Weight: 253.89
• EINECS: 215-860-4
• Product Categories: Bromine Compounds;Fluorine Compounds;Fluorobenzene Series;Aryl;C6;Halogenated Hydrocarbons
• Mol File: 1435-51-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 204-206 °C768 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: clear light yellow liquid
• Density: 2.018 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.234mmHg at 25°C
• Refractive Index: n20/D 1.577(lit.)
• Storage Temp.: Room temperature.
• BRN: 2353462
• CAS DataBase Reference: 1,3-Dibromo-5-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dibromo-5-fluorobenzene(1435-51-4)
• EPA Substance Registry System: 1,3-Dibromo-5-fluorobenzene(1435-51-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1435-51-4(Hazardous Substances Data)

Usage

Description

1,3-Dibromo-5-fluorobenzene is an aryl fluorinated building block, characterized as a clear light yellow liquid. It serves as a key intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
1,3-Dibromo-5-fluorobenzene is used as a synthetic intermediate for the preparation of ligand 5-fluoro-1,3-di(2-pyridyl)benzene, which is crucial in the development of new pharmaceutical compounds. This is achieved through a Stille reaction with 2-(tri-nbutylstannyl)pyridine, a widely employed method in organic synthesis for the formation of carbon-carbon bonds.
Used in Chemical Industry:
In the chemical industry, 1,3-Dibromo-5-fluorobenzene is utilized as a building block for the synthesis of various complex organic molecules and specialty chemicals. Its unique combination of bromine and fluorine atoms allows for a range of reactions and functional group transformations, making it a valuable component in the development of novel materials and compounds with specific properties and applications.

InChI:InChI=1/C6H3Br2F/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 348-54-9 2-Fluoroaniline 
• 618-87-1 3, 5-dinitroaniline 
• 62720-29-0 1,3-dibromo-5-fluoro-2-iodobenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 176548-70-2 3-bromo-5-fluorobenzoic acid 
• 765302-44-1 C₁₃H₉BrClFO 
• 893417-47-5 3-(3-bromo-5-fluoro-phenyl)-thiophene 
• 205683-34-7 2,4-dibromo-6-fluorobenzaldehyde 
• 188813-02-7 3-bromo-5-fluorobenzaldehyde 
• 915410-93-4 1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene 
• 938467-02-8 2,6-dibromo-4-fluorobenzaldehyde 
• 626-41-5 3,5-dibromophenol 
• 1123157-93-6 3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenol 
• 1416141-89-3 C₂₁H₁₇BrO₄ 
• 1261947-54-9 3-(benzo[d][1,3]dioxol-5-yl)-5-bromophenol 
• 1416141-92-8 C₂₅H₂₀O₄S 
• 1123157-92-5 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-ethoxycarbonylethyl)phenoxy}butyric acid ethyl ester 
• 1123155-95-2 4-{3-[6-(3-(benzo[1,3]dioxol-5-yl)-5-(thiophen-3-yl)phenoxy)hexyl]-2-(2-carboxyethyl)phenoxy}butyric acid 

Relevant articles and documents

A green environmental protection of the bromobenzene [...] preparation method (by machine translation)

The present invention provides a green environmental protection of the bromobenzene [...] preparation method, comprises the following steps: sulfuric acid and [...] aniline added in a reaction kettle, stirring cooling to 5 - 10 °C, thermal insulation and slowly instillment bromide, dropping after the completion of the slow heating to 15 - 20 °C, thermal insulation and dropping hydrogen peroxide solution, the constant temperature reaction, again lowering the temperature to 0 - 5 °C, thermal insulation and dropping nitroso sulfuric acid, thermal insulation reaction, slow heating to 35 - 40 °C, thermal insulation and dropping isopropyl alcohol and water mixture, after dropping the stirring, heating up to 55 - 60 °C, thermal insulation, layered, separation [...] and oil reservoir; the oil reservoir is arranged in the rectification apparatus, first heating up to 65 - 70 °C, after the heat preservation, heating up to 83 - 85 °C, distillation separation, to obtain [...] bromobenzene and 3, 5 - dibromide fluoride; the water through distillation, obtained from the isopropyl alcohol, a mixture of water and acetone and sulfuric acid, the isopropanol, water and the mixture for catalytic hydrogenation, to obtain the isopropanol-water solution. (by machine translation)

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.