143815-52-5Relevant articles and documents
TRPV4 activity inhibitor
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Paragraph 0099; 0104-0107, (2020/05/16)
PROBLEM TO BE SOLVED: To provide a compound that inhibits TRPV4 activity and is useful for prevention or improvement of overactive bladder and irritable bowel syndrome or the like. SOLUTION: A TRPV4 activity inhibitor has a rosmarinic acid derivative selected from the formulae (Ia)-(Id) or a salt thereof as an active ingredient. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor
Queffelec, Clemence,Bailly, Fabrice,Mbemba, Gladys,Mouscadet, Jean-Francois,Debyser, Zeger,Witvrouw, Myriam,Cotelle, Philippe
, p. 2268 - 2271 (2008/12/23)
A successful synthesis of fukiic acid is described in 7% overall yield (6 steps from veratraldehyde). rac-Fukiic acid was found to be a potent inhibitor of HIV-1 integrase but did not reveal any antiviral activity in the MT-4 cells assay.
A modified synthesis of (±)-β-aryllactic acids
Wong,Xu,Chang,Lee
, p. 793 - 797 (2007/10/02)
The synthesis of racemic forms of the reportedly active principle of Danshen, namely (±)-β-(3,4-dihydroxyphenyl)lactic acid [(±)3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid] and its seven racemic derivatives is reported.