1443684-70-5

Basic information

• Product Name: 2-chloro-6-fluorophenyl trifluoromethanesulfonate
• Synonyms: 2-chloro-6-fluorophenyl trifluoromethanesulfonate
• CAS NO: 1443684-70-5
• Molecular Weight: 278.612
• Mol File: 1443684-70-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-fluorophenyl trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-fluorophenyl trifluoromethanesulfonate(1443684-70-5)
• EPA Substance Registry System: 2-chloro-6-fluorophenyl trifluoromethanesulfonate(1443684-70-5)

Safety Data

• Hazardous Substances Data: 1443684-70-5(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 2040-90-6 2-chloro-6-fluorophenol 
• 1025373-45-8 trifluoromethanesulfonic acid anhydride 

Downstream Products

• 1416266-74-4 1-chloro-2-ethynyl-3-fluoro-benzene 
• 1443750-38-6 2-chloro-4-(2-chloro-6-fluoro-phenylethynyl)-pyrimidin-5-ylamine 
• 1443750-39-7 2-chloro-6-(2-chloro-6-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidine 
• 1443750-31-9 4-[6-(2-chloro-6-fluoro-phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl]-3,N,N-trimethyl-benzenesulfonamide 
• 1443750-42-2 5-bromo-3-(2-chloro-6-fluoro-phenylethynyl)-pyrazin-2-ylamine 
• 1443750-43-3 2-bromo-6-(2-chloro-6-fluoro-phenyl)-5H-pyrrolo[2,3-b]pyrazine 
• 1443750-35-3 6-(2-chloro-6-fluorophenyl)-2-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-5H-pyrrolo[2,3-b]pyrazine 
• 1443684-71-6 [(2-chloro-6-fluorophenyl)ethynyl](trimethyl)silane 

Relevant articles and documents

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE

The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

7-AZAINDOLE INHIBITORS OF CRAC

Disclosed are compounds of Formula (I), useful for treatment of autoimmune and inflammatory diseases associated with IL-2 inhibition via modulation of calcium release-activated calcium (CRAC) channels. Also disclosed are methods of making and using the compounds for treatment of diseases associated with CRAC channels.