1445719-53-8 Usage
Description
4-(2-amino-3,5-dibromobenzylamino)cyclohexanone is an organic compound with a complex molecular structure. It is characterized by the presence of an amino group attached to a 3,5-dibromobenzyl moiety, which is further connected to a cyclohexanone ring. 4-(2-amino-3,5-dibromobenzylamino)cyclohexanone is known to be an impurity associated with certain pharmaceuticals, specifically Ambroxol and its metabolite Bromhexine.
Uses
Used in Pharmaceutical Industry:
4-(2-amino-3,5-dibromobenzylamino)cyclohexanone is used as an impurity in the production of Ambroxol (A575900), a bronchosecretolytic drug that helps in the treatment of respiratory disorders by thinning and reducing the viscosity of bronchial secretions. It is also found as an impurity in the metabolite of Bromhexine (B678600), which is used for similar therapeutic purposes.
The compound's presence as an impurity highlights the need for careful monitoring and control during the synthesis and manufacturing processes of these drugs to ensure the safety and efficacy of the final pharmaceutical product. Additionally, understanding the properties and potential effects of this compound can aid in the development of improved drug formulations and the management of side effects associated with the use of Ambroxol and Bromhexine.
Check Digit Verification of cas no
The CAS Registry Mumber 1445719-53-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,5,7,1 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1445719-53:
(9*1)+(8*4)+(7*4)+(6*5)+(5*7)+(4*1)+(3*9)+(2*5)+(1*3)=178
178 % 10 = 8
So 1445719-53-8 is a valid CAS Registry Number.
1445719-53-8Relevant articles and documents
Highly efficient aerobic oxidation of alcohols by using less-hindered nitroxyl-radical/copper catalysis: Optimum catalyst combinations and their substrate scope
Sasano, Yusuke,Kogure, Naoki,Nishiyama, Tomohiro,Nagasawa, Shota,Iwabuchi, Yoshiharu
, p. 1004 - 1009 (2015/03/31)
The oxidation of alcohols into their corresponding carbonyl compounds is one of the most fundamental transformations in organic chemistry. In our recent report, 2-azaadamantane N-oxyl (AZADO)/copper catalysis promoted the highly chemoselective aerobic oxidation of unprotected amino alcohols into amino carbonyl compounds. Herein, we investigated the extension of the promising AZADO/copper-catalyzed aerobic oxidation of alcohols to other types of alcohol. During close optimization of the reaction conditions by using various alcohols, we found that the optimum combination of nitroxyl radical, copper salt, and solution concentration was dependent on the type of substrate. Various alcohols, including highly hindered and heteroatom-rich ones, were efficiently oxidized into their corresponding carbonyl compounds under mild conditions with lower amounts of the catalysts.
