1445828-42-1

Basic information

• Product Name: (2R,3S)-1-(2,4,5-trichlorophenoxy)-4-(tert-butyldimethylsiloxy)-3-(benzyloxy)butan-2-ol
• Synonyms: (2R,3S)-1-(2,4,5-trichlorophenoxy)-4-(tert-butyldimethylsiloxy)-3-(benzyloxy)butan-2-ol
• CAS NO: 1445828-42-1
• Molecular Weight: 505.941
• Mol File: 1445828-42-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3S)-1-(2,4,5-trichlorophenoxy)-4-(tert-butyldimethylsiloxy)-3-(benzyloxy)butan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-1-(2,4,5-trichlorophenoxy)-4-(tert-butyldimethylsiloxy)-3-(benzyloxy)butan-2-ol(1445828-42-1)
• EPA Substance Registry System: (2R,3S)-1-(2,4,5-trichlorophenoxy)-4-(tert-butyldimethylsiloxy)-3-(benzyloxy)butan-2-ol(1445828-42-1)

Safety Data

• Hazardous Substances Data: 1445828-42-1(Hazardous Substances Data)

Upstream product

• 933-78-8 2,3,5-trichlorophenol 

Relevant articles and documents

Co(iii)(salen)-catalyzed phenolic kinetic resolution of two stereocentered benzyloxy and azido epoxides: Its application in the synthesis of ICI-118,551, an anti-hypertensive agent

The salen Co(iii)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti- or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a β-blocker, in a highly optically pure form (99% ee). the Partner Organisations 2014.

PHENOLYTIC KINETIC RESOLUTION OF AZIDO AND ALKOXY EPOXIDES

Disclosed herein is a single step catalytic process for the production of enantiomerically pure ?-Aryloxy-?'-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and syn azido/alkoxy epoxides to generate two stereocentres of high optical purities of formula (A). Formula A