1446138-83-5 Usage
Description
Ethanone, 2-bromo-1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)-, also known as 2-bromo-1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)ethanone, is an organic chemical compound with the molecular formula C15H8Br2F2O. It is characterized by the presence of bromine, fluorine, and oxygen atoms in its structure, which imparts unique properties to the molecule. Ethanone, 2-broMo-1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)is utilized in various applications, including the synthesis of pharmaceuticals and agrochemicals, as well as serving as a reagent in organic chemistry reactions for the preparation of complex organic molecules.
Uses
Used in Pharmaceutical Synthesis:
Ethanone, 2-bromo-1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)is employed as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure, featuring bromine and fluorine atoms, allows for the development of new drugs with improved properties, such as enhanced efficacy, selectivity, and reduced side effects.
Used in Agrochemical Synthesis:
Ethanone, 2-broMo-1-(7-broMo-9,9-difluoro-9H-fluoren-2-yl)is also utilized in the synthesis of agrochemicals, contributing to the development of new pesticides, herbicides, and other agricultural products. The presence of bromine and fluorine in the molecule enables the creation of agrochemicals with increased effectiveness and selectivity, leading to better crop protection and yield.
Used as a Reagent in Organic Chemistry Reactions:
Ethanone, 2-bromo-1-(7-bromo-9,9-difluoro-9H-fluoren-2-yl)serves as a valuable reagent in organic chemistry, particularly in the preparation of complex organic molecules. Its unique properties allow for versatile reactions, enabling the synthesis of a wide range of organic compounds with potential applications in various industries.
Used in Research and Development:
Due to its unique structure and properties, this compound is also used in research and development settings to explore new chemical reactions, synthesis methods, and potential applications in various fields, including materials science, nanotechnology, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 1446138-83-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,1,3 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1446138-83:
(9*1)+(8*4)+(7*4)+(6*6)+(5*1)+(4*3)+(3*8)+(2*8)+(1*3)=165
165 % 10 = 5
So 1446138-83-5 is a valid CAS Registry Number.
1446138-83-5Relevant articles and documents
HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS
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, (2017/12/17)
A series of hepatitis C virus (HCV) inhibitors and compositions and applications thereof in the preparation of drugs for treating chronic HCV infection. Especially, a series of compounds that are used as NS5A inhibitors, and compositions and uses thereof in the preparations of drugs.
Discovery of ledipasvir (GS-5885): A potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection
Link, John O.,Taylor, James G.,Xu, Lianhong,Mitchell, Michael,Guo, Hongyan,Liu, Hongtao,Kato, Darryl,Kirschberg, Thorsten,Sun, Jianyu,Squires, Neil,Parrish, Jay,Keller, Terry,Yang, Zheng-Yu,Yang, Chris,Matles, Mike,Wang, Yujin,Wang, Kelly,Cheng, Guofeng,Tian, Yang,Mogalian, Erik,Mondou, Elsa,Cornpropst, Melanie,Perry, Jason,Desai, Manoj C.
supporting information, p. 2033 - 2046 (2014/04/03)
A new class of highly potent NS5A inhibitors with an unsymmetric benzimidazole-difluorofluorene-imidazole core and distal [2.2.1]azabicyclic ring system was discovered. Optimization of antiviral potency and pharmacokinetics led to the identification of 39 (ledipasvir, GS-5885). Compound 39 (GT1a replicon EC50 = 31 pM) has an extended plasma half-life of 37-45 h in healthy volunteers and produces a rapid >3 log viral load reduction in monotherapy at oral doses of 3 mg or greater with once-daily dosing in genotype 1a HCV-infected patients. 39 has been shown to be safe and efficacious, with SVR12 rates up to 100% when used in combination with direct-acting antivirals having complementary mechanisms.
