1446357-39-6Relevant articles and documents
Expeditive access to 2-substituted 4 h -pyrido[1,3]oxazin-4-ones via an intramolecular O-arylation
Slowinski, Franck,Ben Ayad, Omar,Ziyaret, Ozge,Botuha, Candice,Le Falher, Laetitia,Aouane, Kamel,Thorimbert, Serge
supporting information, p. 3494 - 3497 (2013/08/15)
Unreported 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones are synthesized via an unprecedented intramolecular O-arylation of N-aroyl- and N-heteroaroyl-(iso)nicotinamides under microwave irradiations, in good to excellent yields. The broad applicability was demonstrated by 24 examples with a variety of substituents at the 2-position of the final compounds and 3 possible positions for the nitrogen atom of the pyridine ring. In addition, transformation of one of these compounds into 2-hydroxypyridyl-substituted 1,2,4-triazole and 1,2,4-oxazinone was realized. This approach opens a rapid access to a new bicyclic heteroaromatic chemical series with high potential in medicinal chemistry.