144836-49-7

Basic information

• Product Name: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 144836-49-7
• Molecular Formula: C10H12N2O2S
• Molecular Weight: 224.28
• Mol File: 144836-49-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(144836-49-7)
• EPA Substance Registry System: 2,6-DIMETHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(144836-49-7)

Safety Data

• Hazardous Substances Data: 144836-49-7(Hazardous Substances Data)

Usage

Structure

Ester derivative of thiazole-5-carboxylic acid containing a 2,6-dimethylimidazo ring (a five-membered ring with two methyl groups attached to it, and a thiazole ring attached to the nitrogen atom)

Usage

Building block for the synthesis of various biologically active compounds (commonly used in pharmaceutical and chemical research to create compounds with potential medicinal properties)

Application

Development of new drug candidates (due to its potential medicinal properties)

Application

Development of agrochemicals (chemicals used in agriculture to control pests and diseases)

Application

Material science (study of materials and their properties, including their development and application)

Upstream product

• 7305-71-7 5-methyl-2-thiazol-2-amine 
• 84911-18-2 ethyl 2-bromoacetoacetate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 

Downstream Products

• 1007875-19-5 2,6-dimethylimidazo[2,1-b]thiazole-5-carboxylic acid 

Relevant articles and documents

BENZYL AMINE-CONTAINING HETEROCYCLIC COMPOUNDS AND COMPOSITIONS USEFUL AGAINST MYCOBACTERIAL INFECTION

Described herein are compounds and compositions, and methods of making and their use as effective agents against mycobacterial infections.

3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to 3-aza-bicyclo[3.1.0]hexane derivatives of formula (I) wherein A, B, n, X, and R1 are as described in the description, and salts thereof, and their use as orexin receptor antagonists.

Reaction of 2-Aminothiazoles with Reagents containing a C-Halogen and a C=O Electrophilic Centre

Seven reagents of different types having in common a C-Hal and a C=O electrophilic centre have been used in a study of their reactions with 2-aminothiazoles.Three reagents, CHBrAc2 and ROCHBrCO2Et (R = Me, Ph), gave imidazothiazoles, thus providing useful routes to the 5-acetyl and 5-ethoxycarbonyl derivatives.Unexpectedly, the solvent (acetone) was involved in the reaction of the fourth reagent, CHBr(CO2Et)2, with 2-aminothiazole which led to 5,5-di(ethoxycarbonyl)-6,6-dimethyl-5,6-dihydroimidazothiazole (yield 81percent).With the last three reagents (AcCHBrNO2, BzCHBrCN and ICH2CO2C6H4NO2-p) the outcome was simpler, viz., the formation of 2-amidothiazoles.It is proposed that electrophilic attack by the endo-N of the 2-aminothiazole is the first step in all cases.This occurs at the C-Hal centre of the first four reagents and is followed by cyclisation to the exo-N.In the last three electrophiles the presence of the groups well suited to leaving as stabilised anions favours addition to the C=O group; the intermediates so formed subsequently isomerise to the more stable exo-N substituted products.