144979-12-4Relevant articles and documents
Lactone radical cyclizations and cyclization cascades mediated by SmI 2-H2O
Parmar, Dixit,Matsubara, Hiroshi,Price, Kieran,Spain, Malcolm,Procter, David J.
supporting information; experimental part, p. 12751 - 12757 (2012/09/05)
Unsaturated lactones undergo reductive radical cyclizations upon treatment with SmI2-H2O to give decorated cycloheptanes in a single highly selective operation during which up to three contiguous stereocenters are generated. Furthermore, cascade processes involving lactones bearing two alkenes, an alkene and an alkyne, or an allene and an alkene allow "one-pot" access to biologically significant molecular scaffolds with the construction of up to four contiguous stereocenters. The cyclizations proceed by the trapping of radical anions formed by electron transfer reduction of the lactone carbonyl.
A new entry to 1,5-keto esters and their 4,4-dideuterio derivatives via methylene chloride as methylene dianion equivalents
Lin, Kuo-Wei,Chen, G-Yih,Chen, Wei-Fan,Yan, Tu-Hsin
, p. 4759 - 4761 (2008/09/20)
(Chemical Equation Presented) This TiCl4-Mg promoted multicomponent coupling of various amides with CH2Cl2 and methyl acrylate represents an extremely simple and practical synthesis of 1,5-keto esters. The efficiency of this chemistry is illustrated by the very simple preparation of unusual 4,4-dideuterio- 1,5-keto esters.
Oxidative cleavage of the C-C bond of 3,6-dialkylcyclohexane-1,2-diones by cell suspension cultures of Marchantia polymorpha
Matsuura, Yoshitomo,Chai, Wen,Endoh, Etsuko,Suhara, Jyumpei,Hamada, Hiroki,Horiuchi, C. Akira
, p. 669 - 673 (2007/10/03)
Biotransformation of 3,6-dialkylcyclohexane-1,2-diones by cell suspension cultures of Marchantia polymorpha involves regio-selective oxidative cleavage of the C-C bond to give the corresponding oxocarboxylic acids shortened by one carbon unit. In the case of cyclohexane-1,2-dione, adipic acid was obtained.
