145163-97-9

Basic information

• Product Name: 3beta-Hydroxyporiferast-5-en-7-one
• Synonyms: 3beta-Hydroxyporiferast-5-en-7-one;24(S)-3beta-Hydroxystigmast-5-en-7-one;3β-Hydroxyporiferast-5-en-7-one
• CAS NO: 145163-97-9
• Molecular Formula: C29H48O2
• Molecular Weight: 429
• Mol File: 145163-97-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3beta-Hydroxyporiferast-5-en-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3beta-Hydroxyporiferast-5-en-7-one(145163-97-9)
• EPA Substance Registry System: 3beta-Hydroxyporiferast-5-en-7-one(145163-97-9)

Safety Data

• Hazardous Substances Data: 145163-97-9(Hazardous Substances Data)

Usage

General Description

3beta-Hydroxyporiferast-5-en-7-one is a chemical compound typically found in marine organisms, particularly sponges. It belongs to the group of chemicals termed marine steroids which are known for their diverse range of structures and bioactivities. However, there is significantly less information available regarding this specific compound, including its exact structure and potential biological effects or applications. Researchers continuously study marine steroids like 3beta-Hydroxyporiferast-5-en-7-one to uncover their potential uses within the pharmaceutical industry, particularly in developing new therapeutic drugs.

Upstream product

• 145163-98-0 stigmast-3β,7β-dihydroxyl-5-ene 
• 145985-28-0 7-oxo-poriferast-5-en-3β-yl-acetate 
• 145985-27-9 Acetic acid (3S,7R,8S,9S,10R,13R,14S,17R)-3-acetoxy-17-((1R,4S)-4-ethyl-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl ester 
• 18376-53-9 (24R)-3β-acetoxystigmast-5-en-7-one 
• 32345-19-0 24-ethylcholesta-5,22-dien-3β-ol 
• 1900-46-5 β-sitosterol acetate 
• 134876-41-8 3β,Δ⁴-stigmasten-3-ol 
• 53139-42-7 stigmasteryl tosylate 
• 915-05-9 stigmast-5-en-3-yl acetate 
• 83-46-5 β-sitosterol 
• 108646-29-3 22,23-dihydro-i-stigmasterol methyl ether 
• 163058-95-5 3β-acetoxyclionast-5-ene-7β-ol 
• 4651-54-1 3β-acetoxysitosterol 
• 145985-29-1 stigmast-3β,7α-dihydroxyl-5-ene 

Downstream Products

• 4863-54-1 5-stigmasten-3β,7β-diol 
• 521-03-9 22-dihydrospinasterol 
• 2034-72-2 poriferasta-3,5-dien-7-one 

Relevant articles and documents

DIHYDROXYSTEROLS FROM THE MARINE RED ALGA, GRACILARIA EDULIS

Two minor C29 dihydroxysteroids, poriferast-5-en-3β,7β-diol and 5α-poriferastane-3β,6α-diol have been isolated from the chloroform extract of the marine red alga, Gracilaria edulis. Key Word Index: Gracilaria edulis; Gracilariaceae; marine red alga; sterols; poriferast-5-en-3β,7β-diol; 5α-poriferastane-3β,6α-diol.

Synthesis and search for 3β,3′β-disteryl ethers after high-temperature treatment of sterol-rich samples

It has been proven that at increased temperature, sterols can undergo various chemical reactions e.g., oxidation, dehydrogenation, dehydration and polymerisation. The objectives of this study are to prove the existence of dimers and to quantitatively analyse the dimers (3β,3′β-disteryl ethers). Sterol-rich samples were heated at 180 °C, 200 °C and 220 °C for 1 to 5 h. Quantitative analyses of the 3β,3′β-disteryl ethers were conducted using liquid extraction, solid-phase extraction and gas chromatography coupled with mass spectrometry. Additionally, for the analyses, suitable standards were synthetized from native sterols. To identify the mechanism of 3β,3′β-disteryl ether formation at high temperatures, an attempt was made to use the proposed synthesis method. Additionally, due to the association of sterols and sterol derivatives with atherosclerosis, preliminary studies with synthetized 3β,3′β-disteryl ethers on endothelial cells were conducted.

An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system

Abstract Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and

Sterols as anticancer agents: Synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis

The cytotoxicity of oxysterols was systematically studied in tumor and normal cells. Synthetic strategies to prepare this library included oxidations at ring B and a new method to yield 6β-hemiphthalates directly from Δ5-steroids. Most oxysterols were cytotoxic and showed selectivity toward cancer cells, LAMA-84 cells (leukemia) being particularly sensitive to 4, 8, 22, and 27 (IC50 5.6 μM). The structural requirements to induce selective toxicity are discussed to shed light on the development of new anticancer drugs.