145285-58-1Relevant articles and documents
Sharpless Asymmetric Dihydroxylation on α,β-Unsaturated Diazoketones: A New Entry for the Synthesis of Disubstituted Furanones
Talero, Alexánder G.,Burtoloso, Antonio C. B.
, p. 1748 - 1752 (2017)
The synthesis of enantiomerically pure 4,5-disubstituted 2-furanones is accomplished in three steps from aldehydes. The steps involve a highly enantioselective Sharpless asymmetric dihydroxylation of α,β-unsaturated diazoketones, followed by a photochemical Wolff rearrangement.
Short and efficient synthesis of cryptophycin unit A
Eissler, Stefan,Nahrwold, Markus,Neumann, Beate,Stammler, Hans-Georg,Sewald, Norbert
, p. 817 - 819 (2007/10/03)
(Chemical Equation Presented) Two short synthetic approaches toward cryptophycin unit A comprise a catalytic asymmetric dihydroxylation as the sole source of chirality, while all further stereogenic centers are introduced under substrate control. The key
A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (-)- and (+)-muricatacin
Wang,Zhang,Sharpless,Sinha,Sinha Bagchi,Keinan
, p. 6407 - 6410 (2007/10/02)
Both enantiomers of hydroxy γ-lactones have been prepared highly enantioselectively (92-99% ee) using either AD-mix-β or AD-mix-α with both β,γ- and γ,δ-unsaturated esters. The method is exemplified by the three-step synthesis of (-) and (+)-muricatacin i
