145285-60-5

Basic information

• Product Name: (4S,5S)-4-hydroxy-5-phenyldihydrofuran-2(3H)-one
• Synonyms: (4S,5S)-4-hydroxy-5-phenyldihydrofuran-2(3H)-one
• CAS NO: 145285-60-5
• Molecular Weight: 178.188
• Mol File: 145285-60-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4S,5S)-4-hydroxy-5-phenyldihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-4-hydroxy-5-phenyldihydrofuran-2(3H)-one(145285-60-5)
• EPA Substance Registry System: (4S,5S)-4-hydroxy-5-phenyldihydrofuran-2(3H)-one(145285-60-5)

Safety Data

• Hazardous Substances Data: 145285-60-5(Hazardous Substances Data)

Upstream product

• 91083-82-8 (E)-methyl 4-phenylbut-3-enoate 
• 17199-29-0 (S)-Mandelic acid 
• 60646-33-5 (5S)-5-phenyl-1,3-dioxolan-4-one 
• 333459-74-8 [(S)-5-Phenyl-[1,3]dioxolan-(4E)-ylidene]-acetic acid ethyl ester 

Relevant articles and documents

Sharpless Asymmetric Dihydroxylation on α,β-Unsaturated Diazoketones: A New Entry for the Synthesis of Disubstituted Furanones

The synthesis of enantiomerically pure 4,5-disubstituted 2-furanones is accomplished in three steps from aldehydes. The steps involve a highly enantioselective Sharpless asymmetric dihydroxylation of α,β-unsaturated diazoketones, followed by a photochemical Wolff rearrangement.

A general approach to γ-lactones via osmium-catalyzed asymmetric dihydroxylation. Synthesis of (-)- and (+)-muricatacin

Both enantiomers of hydroxy γ-lactones have been prepared highly enantioselectively (92-99% ee) using either AD-mix-β or AD-mix-α with both β,γ- and γ,δ-unsaturated esters. The method is exemplified by the three-step synthesis of (-) and (+)-muricatacin i