1454601-01-4

Basic information

• Product Name: 2-phenyl-3H-benzofuro[3,2-e]benzofuran
• Synonyms: 2-phenyl-3H-benzofuro[3,2-e]benzofuran
• CAS NO: 1454601-01-4
• Molecular Weight: 284.314
• Mol File: 1454601-01-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-3H-benzofuro[3,2-e]benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-3H-benzofuro[3,2-e]benzofuran(1454601-01-4)
• EPA Substance Registry System: 2-phenyl-3H-benzofuro[3,2-e]benzofuran(1454601-01-4)

Safety Data

• Hazardous Substances Data: 1454601-01-4(Hazardous Substances Data)

Upstream product

• 5397-82-0 dibenzofuran-2-carbaldehyde 
• 86-77-1 2-hydroxydibenzofuran 
• 51079-04-0 1-iododibenzo[b,d]furan-2-ol 
• 536-74-3 phenylacetylene 

Relevant articles and documents

Design, synthesis and antitubercular evaluation of novel 2-substituted-3H-benzofuro benzofurans via palladium-copper catalysed Sonagashira coupling reaction

A series of novel natural product like 2-substiuted-3H-benzofurobenzofurans designed by molecular hybridization were synthesized in very good yields. The key reactions involved in the synthesis are iodination of 2-dibenzofuranol using iodine monochloride followed by palladium-copper catalyzed Sonagashira-coupling of 1-iododibenzofuran-2-ol with various alkyl and aryl acetylenes. Among the all 10 new compounds screened for in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv, 2-(4-methoxy-2-methyl phenyl)-3H-benzofuro[3, 2-e]benzofuran (7c) was found to be most active with MIC 3.12 μg/mL and has shown lower cytotoxicity with good therapeutic index.