1456-21-9Relevant articles and documents
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Holmberg
, p. 2,3 (1944)
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Synthesis of 1,3,4-thiadiazoles from aldehyde hydrazones
Okuma, Kentaro,Nagakura, Kazuko,Nakajima, Yasutaka,Kubo, Kento,Shioji, Kosei
, p. 1929 - 1931 (2004)
Reaction of p-tolualdehyde hydrazone with disulfur dichloride in the presence of DBU gave 2,5-di (p-tolyl)-1,3,4-thiadiazole (1a) in 54% yield. Phenyldiazomethane also reacted with disulfur dichloride to afford 2,5-diphenyl-1,3,4-thiadiazole (1b) in 80% y
Synthesis of substituted 1,3,4-thiadiazoles using Lawesson's reagent
Gierczyk,Zalas
, p. 213 - 222 (2005)
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Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking
Gowda, Kemparaje,Kanchugarkoppal, Rangappa S.,Kempegowda, Mantelingu,Nagarakere, Sandhya C.,Rangappa, Shobith,Swarup, Hassan A.
, (2020/04/27)
A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecules developed using substituted aldehydes and substituted dithioesters in presence of NCS (N-Chorosuccinimide). The compounds 4a, 4b, 4c, 4f, and 4k showed good antibacterial and antioxidant activity among which, 4k possess excellent antibacterial and antioxidant activity. The results of antioxidant activity studies revealed that compound 4k manifested profound antioxidant potential. The molecular docking study was performed with respective newly synthesized compounds to ascertain the binding mode of 4k with respect to the critical proteins involved in biosynthesis and metabolic pathways.
A KHSO4 promoted tandem synthesis of 1,3,4-thiadiazoles from thiohydrazides and DMF derivatives
Gan, Zongjie,Tian, Binghua,Yuan, Jianyong,Ran, Dongzhi,Zhang, Lin,Dong, Gang,Pan, Tao,Zeng, Yixin,Yu, Yu
supporting information, (2020/07/15)
An efficient, simple and environmentally benign method for the construction of 1,3,4-thiadiazole skeletons via the tandem coupling and cyclization of thiohydrazides with DMF derivatives in the presence of KHSO4 has been reported. This method re