1457-85-8

Basic information

• Product Name: ETHYL OXANILATE
• Synonyms: Acetic acid, oxo(phenylamino)-, ethyl ester;Ethyl anilino(oxo)acetate;ETHYL OXANILATE;ETHYL 2-ANILINO-2-OXOACETATE;Ethyl oxanilate,98+%;2-(Phenylamino)glyoxylic acid ethyl ester;N-Phenyloxamidic acid ethyl ester;Oxanilic acid ethyl
• CAS NO: 1457-85-8
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• EINECS: 215-945-6
• Product Categories: Amides;Building Blocks;C8 to C20+;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 1457-85-8.mol
• Article Data: 55

Chemical Properties

• Melting Point: 67-69 °C(lit.)
• Boiling Point: 329.41°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.2307 (rough estimate)
• Refractive Index: 1.5300 (estimate)
• PKA: 11.29±0.70(Predicted)
• BRN: 2098703
• CAS DataBase Reference: ETHYL OXANILATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL OXANILATE(1457-85-8)
• EPA Substance Registry System: ETHYL OXANILATE(1457-85-8)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 1457-85-8(Hazardous Substances Data)

Usage

Description

ETHYL OXANILATE is an organic compound with the chemical formula C10H10O3. It is a white crystalline powder known for its unique chemical properties, which make it suitable for various applications across different industries.

Uses

Used in Photo-redox Reactions:
ETHYL OXANILATE is used as a reagent in photo-redox reactions for the synthesis of a variety of organic compounds. Its chemical properties allow it to participate in these reactions, contributing to the formation of new and useful organic molecules.
Used in Chemical Synthesis:
ETHYL OXANILATE is used as an intermediate in the chemical synthesis industry. Its unique structure and reactivity make it a valuable component in the production of various chemicals and pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL OXANILATE is used as a building block for the development of new drugs. Its chemical properties enable it to be incorporated into the molecular structure of potential therapeutic agents, enhancing their efficacy and safety.
Used in Research and Development:
ETHYL OXANILATE is also utilized in research and development laboratories, where it is employed to study the properties and behavior of organic compounds. Its use in these settings helps to advance the understanding of chemical reactions and contributes to the discovery of new compounds with potential applications in various fields.

InChI:InChI=1/C10H11NO3/c1-2-14-10(13)9(12)11-8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H,11,12)

Upstream product

• 62-53-3 aniline 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 64-17-5 ethanol 
• 102-01-2 N-phenylacetoacetamide 
• 924-44-7 glyoxylic acid ethyl ester 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 66552-45-2 Aethyl-2-anilinoacetoacetat 
• 941-69-5 N-phenyl-maleimide 
• 21911-74-0 (methyl-phenyl-amino)-acetic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 102-07-8 bis(diphenyl)urea 
• 7732-18-5 water 
• 74405-85-9 ethyl tetrafluoro‐2‐oxo‐3‐trifluoromethylbutanoate 
• 78366-51-5 Ethoxalyl-isothiocyanat 

Downstream Products

• 72681-68-6 2-oxo-N-phenylbutanamide 
• 2760-38-5 2-hydroxy-2-methylpropionanilide 
• 861609-06-5 N¹-(2-carboxyphenyl)-N²-phenyloxalamide 
• 113449-15-3 N-phenyl-N'-m-tolyl-oxalamide 
• 108988-07-4 oxalic acid anilide-(2,4-dinitro-anilide) 
• 64-17-5 ethanol 
• 74-85-1 ethene 
• 103-71-9 phenyl isocyanate 
• 62-53-3 aniline 
• 861012-10-4 N-cyclohexyl-N'-(4-nitro-phenyl)-oxalamide 
• 74527-54-1 N-cyclohexyl-N'-(2-nitro-phenyl)-oxalamide 
• 51176-78-4 N-cyclohexyl-N'-(2,4-dinitro-phenyl)-oxalamide 
• 861012-03-5 N-cyclohexyl-N'-picryl-oxalamide 
• 1243262-71-6 C₁₄H₂₀N₂O₃ 

Relevant articles and documents

Chemical hybridizing agents for chickpea (Cicer arietinum L.): Leads from QSAR analysis of ethyl oxanilates and pyridones

In the self-pollinated crops such as chickpea, induction of male sterility by deployment of chemical hybridizing agents (CHAs) facilitating "two-line" approach holds immense potential in heterosis breeding. A total of 40 test CHAs comprising 20 ethyl oxanilates and 20 pyridones were screened as potential CHAs on chickpea (variety BG 1088) at 500, 800, and 1000 ppm. Three test compounds mostly having either F (4)/Br (5)/CF3 (19) at the para position of the aryl ring from a pool of 20 ethyl oxanilates were identified as the most potent CHAs causing >99% induction of pollen sterility and >90% total flower sterility at 1000-ppm test concentration. Among pyridone derivatives, N-(4-chlorophenyl)-5-carbethoxy-4,6-dimethyl, 1,2-dihydropyrid-2-one (26) was found to be the most active. Quantitative structure activity relationship (QSAR) analysis has revealed a direct involvement of Swain-Lupton field constant, Fp, with the target bioactivity which implied that field rather than resonance effect (R) had a positive effect on the activity. The real guiding principle for selectivity was found out to be the hydrophobic parameter π value. The QSAR models indicated that increased steric bulk at the 4-position on the phenyl ring is associated with enhanced activity. The CHAs appeared to act by mimicking UDP-glucose, the key substrate in the synthesis of callose, or lead to an imbalance in acid-base equilibrium in pollen mother cells resulting in dissolution of callose wall by premature callase secretion.

Ethyl N-phenyloxamate

The crystalline structure of the ethyl N-phenyloxamate was studied. The infrared spectrophotometer and the nuclear magnetic resonance (NMR) spectra were used for the study. The supermolecular structure that was achieved through intermolecular hard and soft hydrogen bonding interaction, was also discussed.

Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key intermediates ethyl 1-aryl-1H-tetrazole-5-carboxylates 10 can be simply and efficiently prepared via a microwave-assisted continuous operation process. Among the compounds synthesised, compound 6–31 showed noteworthy potency against SGC-7901, A549 and HeLa cell lines. In mechanism studies, compound 6–31 inhibited tubulin polymerisation and disorganised microtubule in SGC-7901 cells by binding to tubulin. Moreover, compound 6–31 arrested SGC-7901cells in G2/M phase. This study provided a new perspective for development of antitumor agents that target tubulin.

MANUFACTURING INTERMEDIATE AND MANUFACTURING METHOD OF POLYMERIZABLE COMPOUND

PROBLEM TO BE SOLVED: To provide a manufacturing intermediate hardly generating discoloration and change of haze, when ultraviolet is radiated to a film-shaped polymer obtained by manufacturing a polymerizable compound and polymerizing a polymerizable composition containing the compound, and a manufacturing method of the manufacturing intermediate. SOLUTION: There are provided a compound represented by the formula (II), a manufacturing method of the compound, a polymerizable compound manufactured from the compound, a polymerizable composition, a polymer obtained by polymerizing the polymerizable composition, and an optical isomer using the polymer. In the formula, R1, R2 and L1 represent organic groups, n1 represents an integer of 1 to 4, when a plurality of L1 exist, it may be same or different, and neighboring L1 each other may form a condensed ring. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT