1459775-51-9

Basic information

• Product Name: 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one
• Synonyms: 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one
• CAS NO: 1459775-51-9
• Molecular Weight: 290.149
• Mol File: 1459775-51-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one(1459775-51-9)
• EPA Substance Registry System: 3-(3,4-dichloro-phenyl)quinolin-2(1H)-one(1459775-51-9)

Safety Data

• Hazardous Substances Data: 1459775-51-9(Hazardous Substances Data)

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 37630-23-2 1,2-dichloro-4-(2-nitrovinyl)benzene 
• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Metal-free ring expansion of indoles with nitroalkenes: A simple, modular approach to 3-substituted 2-quinolones

3-Substituted 2-quinolones are obtained via a novel metal-free transannulation reaction of 2-nitroolefins with 2-substituted indoles in polyphosphoric acid. This acid-mediated cascade transformation operates via the ANRORC (Addition of Nucleophile, Ring Opening, and Ring Closure) mechanism and can be used in combination with the Fisher indole synthesis to offer a practical three-component hetero-annulation approach to 2-quinolones from arylhydrazines, 2-nitroalkenes, and acetophenone. An alternative entry to this chemistry employing the alkylation of electron-rich arenes and hetarenes with 1-(2-indolyl)-2-nitroalkene has also been demonstrated.