1467083-09-5 Usage
General Description
Hybridaphniphylline B is a complex chemical compound isolated from the plant Daphniphyllum, which has been traditionally used in Chinese medicine. It possesses unique molecular structures and multiple bioactive properties, making it a promising candidate for drug discovery and development. Its potential pharmacological activities include anticancer, anti-inflammatory, antiviral, and antioxidant effects. The compound's intricate chemical structure also makes it an attractive target for further research and potential modification to enhance its therapeutic potential. Overall, Hybridaphniphylline B holds great promise as a multifunctional drug candidate with diverse pharmacological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 1467083-09-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,6,7,0,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1467083-09:
(9*1)+(8*4)+(7*6)+(6*7)+(5*0)+(4*8)+(3*3)+(2*0)+(1*9)=175
175 % 10 = 5
So 1467083-09-5 is a valid CAS Registry Number.
1467083-09-5Relevant articles and documents
Total Synthesis of Hybridaphniphylline B
Zhang, Wenhao,Ding, Ming,Li, Jian,Guo, Zhicong,Lu, Ming,Chen, Yu,Liu, Lianchao,Shen, Yun-Heng,Li, Ang
, p. 4227 - 4231 (2018)
Hybridaphniphylline B (1) is a Daphniphyllum alkaloid possessing 11 rings and 19 stereocenters. Here we report the first total synthesis of 1 featuring a late-stage intermolecular Diels-Alder reaction of a fully elaborated cyclopentadiene and asperuloside tetraacetate. The diene was prepared on the basis of a scalable route to daphnilongeranin B (4). Claisen rearrangement of an allyl dienol ether was exploited as a key step; the subtle variation of the substrate and use of protic solvents suppressed the undesired Cope rearrangement. Daphniyunnine E (6) and dehydrodaphnilongeranin B (7), two congeners of 4, were also synthesized. The dienophile arose from (+)-genipin through glycosylation and lactonization. A one-pot protocol was developed for the diene formation and Diels-Alder reaction; one of the cycloadducts was converted into 1 through reductive desulfurization and global deacetylation.
