1467738-96-0

Basic information

• Product Name: N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-4-nitro-3-(trifluoromethyl)benzamide
• Synonyms: N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-4-nitro-3-(trifluoromethyl)benzamide
• CAS NO: 1467738-96-0
• Molecular Weight: 448.361
• Mol File: 1467738-96-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-4-nitro-3-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-4-nitro-3-(trifluoromethyl)benzamide(1467738-96-0)
• EPA Substance Registry System: N-(3-(2-amino-6-oxo-1,6-dihydropyrimidin-4-ylamino)-4-methylphenyl)-4-nitro-3-(trifluoromethyl)benzamide(1467738-96-0)

Safety Data

• Hazardous Substances Data: 1467738-96-0(Hazardous Substances Data)

Upstream product

• 1467739-26-9 2-amino-6-(5-amino-2-methylphenylamino)pyrimidin-4(3H)-one 
• 320-38-7 4-nitro-3-(trifluoromethyl)benzoic acid 
• 1467739-25-8 2-amino-6-(2-methyl-5-nitrophenylamino)pyrimidin-4(3H)-one 
• 99-55-8 2-methyl-5-nitroaniline 

Relevant articles and documents

Synthesis of new pyrimidinylaminobenzene derivatives and their antiproliferative activities against melanoma cell line

A series of new diarylamide and diarylurea derivatives possessing pyrimidinylaminobenzene scaffold was synthesized. Their in vitro antiproliferative activities were tested against A375P human melanoma cell line. Among them, compounds 1a-c, k and 2b-d, f, g, j, l showed superior potencies against A375P human melanoma cell line to Sorafenib. In particular, compound 2f possessing 3-fluoro-5-trifluoromethyl moiety exhibited the highest potency with IC50 value in nanomolar scale.