14770-85-5

Basic information

• Product Name: 2-ThiophenaMine, 5-phenyl-
• Synonyms: 2-ThiophenaMine, 5-phenyl-;5-Phenyl-thiophen-2-ylamine
• CAS NO: 14770-85-5
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.25016
• Mol File: 14770-85-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 341.6±30.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.17±0.10(Predicted)
• CAS DataBase Reference: 2-ThiophenaMine, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ThiophenaMine, 5-phenyl-(14770-85-5)
• EPA Substance Registry System: 2-ThiophenaMine, 5-phenyl-(14770-85-5)

Safety Data

• Hazardous Substances Data: 14770-85-5(Hazardous Substances Data)

Usage

General Description

2-Thiophenamine, 5-phenyl- is a chemical compound with the molecular formula C10H9NS. It is also known as 5-phenyl-2-thiophenamine and belongs to the class of organic compounds known as phenylthiophenes. 2-Thiophenamine, 5-phenyl- is a yellow to brown solid and is commonly used in the production of pharmaceuticals and agrochemicals. It has a wide range of applications in the synthesis of various organic compounds, particularly in the field of medicinal chemistry. 2-Thiophenamine, 5-phenyl- has also been studied for its potential anti-inflammatory and antimicrobial properties, making it a versatile and important chemical in the pharmaceutical industry.

Upstream product

• 122-78-1 phenylacetaldehyde 
• 4815-34-3 ethyl 2-amino-5-phenylthiophene-3-carboxylate 
• 883745-73-1 N-(diphenylmethylidene)-5-phenyl-2-thiophenamide 
• 98-80-6 phenylboronic acid 
• 18150-93-1 2-phenyl-5-nitrothiophene 

Downstream Products

• 51672-19-6 N,N'-Bis(4,5-dihydro-6-phenyl-3-pyridazinyl)hydrazin 
• 111298-29-4 1-(5-phenyl-[2]thienylazo)-[2]naphthylamine; hydrochloride 

Relevant articles and documents

Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution

An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize hydroxyalkylation on heterocycles such as indoles or thiophenes by means of Lewis acid as catalyst. Additionally, amine functions are rarely free when carbonyl reagents are used because of their tendency to form imines. This is the first time that a site-selective electrophilic aromatic substitution on C3 atom of an unprotected 5-phenylthiophen-2amine moiety is reported. The liberty to allow reaction in neutral conditions between free amine is valuable in a synthesis pathway. The reaction proceeds smoothly using an atom-economical metaland catalyst-free methodology in good to excellent yields. A mechanism similar to an electrophilic aromatic substitution has been proposed.

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators

We previously reported diarylurea derivatives as cannabinoid type-1 receptor (CB1) allosteric modulators, which were effective in attenuating cocaine-seeking behavior. Herein, we extended the structure-activity relationships of PSNCBAM-1 (2) at the central phenyl ring directly connected to the urea moiety. Replacement with a thiophene ring led to 11 with improved or comparable potencies in calcium mobilization, [35S]GTPγS binding, and cAMP assays, whereas substitution with nonaromatic rings led to significant attenuation of the modulatory activity. These compounds had no inverse agonism in [35S]GTPγS binding, a characteristic that is often thought to contribute to adverse psychiatric effects. While 11 had good metabolic stability in rat liver microsomes, it showed modest solubility and blood-brain barrier permeability. Compound 11 showed an insignificant attenuation of cocaine seeking behavior in rats, most likely due to its limited CNS penetration, suggesting that pharmacokinetics and distribution play a role in translating the in vitro efficacy to in vivo behavior.